Literature DB >> 21288008

Copper catalyzed C-H functionalization for direct Mannich reactions.

Magnus Rueping1, Nikita Tolstoluzhsky.   

Abstract

A protocol for a practical and direct addition of α- and γ-alkyl azaarenes to N-sulfonyl aldimines has been developed. Copper salts act as efficient Lewis acid catalysts for direct Mannich-type reactions providing a mild and fast access to various functionalized heterocycles.

Entities:  

Year:  2011        PMID： 21288008     DOI： 10.1021/ol103150g

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  4 in total

1.  Convergent Synthesis of α-Branched Amines by Transition-Metal-Catalyzed C-H Bond Additions to Imines.

Authors:  Joshua R Hummel; Jonathan A Ellman
Journal:  Isr J Chem       Date:  2017-06-29       Impact factor: 3.333

2.  A highly site-selective radical sp3 C-H amination of azaheterocycles.

Authors:  Keith W Bentley; Krysta A Dummit; Jeffrey F Van Humbeck
Journal:  Chem Sci       Date:  2018-07-10       Impact factor: 9.825

3.  Pyridylic anions are soft nucleophiles in the palladium-catalyzed C(sp3)-H allylation of 4-alkylpyridines.

Authors:  Nour Wasfy; Faizan Rasheed; Raphaël Robidas; Isabelle Hunter; Jiaqi Shi; Brian Doan; Claude Y Legault; Dan Fishlock; Arturo Orellana
Journal:  Chem Sci       Date:  2020-12-10       Impact factor: 9.825

4.  Acetic Acid Promoted Redox Annulations with Dual C-H Functionalization.

Authors:  Zhengbo Zhu; Daniel Seidel
Journal:  Org Lett       Date:  2017-05-16       Impact factor: 6.005
  4 in total

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