Literature DB >> 21287333

In vivo Treg suppression assays.

Creg J Workman1, Lauren W Collison, Maria Bettini, Meenu R Pillai, Jerold E Rehg, Dario A A Vignali.   

Abstract

To fully examine the functionality of a regulatory T cell (T(reg)) population, one needs to assess their ability to suppress in a variety of in vivo models. We describe five in vivo models that examine the suppressive capacity of T(regs) upon different target cell types. The advantages and disadvantages of each model including resources, time, and technical expertise required to execute each model are also described.

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Year:  2011        PMID： 21287333      PMCID： PMC3049949          DOI： 10.1007/978-1-61737-979-6_9

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  31 in total

1.  Cutting edge: cure of colitis by CD4+CD25+ regulatory T cells.

Authors:  Christian Mottet; Holm H Uhlig; Fiona Powrie
Journal:  J Immunol       Date:  2003-04-15       Impact factor: 5.422

2.  Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse.

Authors:  M E Brunkow; E W Jeffery; K A Hjerrild; B Paeper; L B Clark; S A Yasayko; J E Wilkinson; D Galas; S F Ziegler; F Ramsdell
Journal:  Nat Genet       Date:  2001-01       Impact factor: 38.330

3.  Characterization of the major histocompatibility complex class I deficiencies in B16 melanoma cells.

Authors:  B Seliger; U Wollscheid; F Momburg; T Blankenstein; C Huber
Journal:  Cancer Res       Date:  2001-02-01       Impact factor: 12.701

4.  Foxp3 programs the development and function of CD4+CD25+ regulatory T cells.

Authors:  Jason D Fontenot; Marc A Gavin; Alexander Y Rudensky
Journal:  Nat Immunol       Date:  2003-03-03       Impact factor: 25.606

Review 5.  Regulatory T cells and inhibitory cytokines in autoimmunity.

Authors:  Maria Bettini; Dario A A Vignali
Journal:  Curr Opin Immunol       Date:  2009-10-23       Impact factor: 7.486

6.  Cutting edge: CD4+CD25+ regulatory T cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitis.

Authors:  Adam P Kohm; Pamela A Carpentier; Holly A Anger; Stephen D Miller
Journal:  J Immunol       Date:  2002-11-01       Impact factor: 5.422

7.  Ex vivo isolation and characterization of CD4(+)CD25(+) T cells with regulatory properties from human blood.

Authors:  D Dieckmann; H Plottner; S Berchtold; T Berger; G Schuler
Journal:  J Exp Med       Date:  2001-06-04       Impact factor: 14.307

8.  Homeostasis-stimulated proliferation drives naive T cells to differentiate directly into memory T cells.

Authors:  B K Cho; V P Rao; Q Ge; H N Eisen; J Chen
Journal:  J Exp Med       Date:  2000-08-21       Impact factor: 14.307

9.  Concomitant tumor immunity to a poorly immunogenic melanoma is prevented by regulatory T cells.

Authors:  Mary Jo Turk; José A Guevara-Patiño; Gabrielle A Rizzuto; Manuel E Engelhorn; Shimon Sakaguchi; Alan N Houghton
Journal:  J Exp Med       Date:  2004-09-20       Impact factor: 14.307

10.  CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms.

Authors:  Kevin J Maloy; Laurence Salaun; Rachel Cahill; Gordon Dougan; Nigel J Saunders; Fiona Powrie
Journal:  J Exp Med       Date:  2003-01-06       Impact factor: 14.307
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  16 in total

1.  IL-10 producing CD8+ CD122+ PD-1+ regulatory T cells are expanded by dendritic cells silenced for Allograft Inflammatory Factor-1.

Authors:  Diana M Elizondo; Temesgen E Andargie; Naomi L Haddock; Ricardo L Louzada da Silva; Tatiana Rodrigues de Moura; Michael W Lipscomb
Journal:  J Leukoc Biol       Date:  2018-12-04       Impact factor: 4.962

2.  The plasticity of regulatory T cell function.

Authors:  Meenu R Pillai; Lauren W Collison; Xiaohua Wang; David Finkelstein; Jerold E Rehg; Kelli Boyd; Andrea L Szymczak-Workman; Teresa Doggett; Thomas S Griffith; Thomas A Ferguson; Dario A A Vignali
Journal:  J Immunol       Date:  2011-10-17       Impact factor: 5.422

Review 3.  Treg Fragility: A Prerequisite for Effective Antitumor Immunity?

Authors:  Abigail E Overacre-Delgoffe; Dario A A Vignali
Journal:  Cancer Immunol Res       Date:  2018-08       Impact factor: 11.151

4.  Cutting edge: regulatory T cells do not mediate suppression via programmed cell death pathways.

Authors:  Andrea L Szymczak-Workman; Greg M Delgoffe; Douglas R Green; Dario A A Vignali
Journal:  J Immunol       Date:  2011-09-26       Impact factor: 5.422

5.  Stress Kinase GCN2 Controls the Proliferative Fitness and Trafficking of Cytotoxic T Cells Independent of Environmental Amino Acid Sensing.

Authors:  Lee-Ann Van de Velde; Xi-Zhi J Guo; Lidija Barbaric; Amber M Smith; Thomas H Oguin; Paul G Thomas; Peter J Murray
Journal:  Cell Rep       Date:  2016-11-22       Impact factor: 9.423

6.  Interferon-γ Drives Treg Fragility to Promote Anti-tumor Immunity.

Authors:  Abigail E Overacre-Delgoffe; Maria Chikina; Rebekah E Dadey; Hiroshi Yano; Erin A Brunazzi; Gulidanna Shayan; William Horne; Jessica M Moskovitz; Jay K Kolls; Cindy Sander; Yongli Shuai; Daniel P Normolle; John M Kirkwood; Robert L Ferris; Greg M Delgoffe; Tullia C Bruno; Creg J Workman; Dario A A Vignali
Journal:  Cell       Date:  2017-05-25       Impact factor: 41.582

7.  T Cells Deficient in the Tyrosine Phosphatase SHP-1 Resist Suppression by Regulatory T Cells.

Authors:  Emily R Mercadante; Ulrike M Lorenz
Journal:  J Immunol       Date:  2017-05-26       Impact factor: 5.422

8.  PD-1 regulates extrathymic regulatory T-cell differentiation.

Authors:  Xiufen Chen; Dominick Fosco; Douglas E Kline; Liping Meng; Saki Nishi; Peter A Savage; Justin Kline
Journal:  Eur J Immunol       Date:  2014-08-18       Impact factor: 5.532

9.  Loss of epigenetic modification driven by the Foxp3 transcription factor leads to regulatory T cell insufficiency.

Authors:  Matthew L Bettini; Fan Pan; Maria Bettini; David Finkelstein; Jerold E Rehg; Stefan Floess; Bryan D Bell; Steven F Ziegler; Jochen Huehn; Drew M Pardoll; Dario A A Vignali
Journal:  Immunity       Date:  2012-05-10       Impact factor: 31.745

10.  Aging imparts cell-autonomous dysfunction to regulatory T cells during recovery from influenza pneumonia.

Authors:  Luisa Morales-Nebreda; Kathryn A Helmin; Manuel A Torres Acosta; Nikolay S Markov; Jennifer Yuan-Shih Hu; Anthony M Joudi; Raul Piseaux-Aillon; Hiam Abdala-Valencia; Yuliya Politanska; Benjamin D Singer
Journal:  JCI Insight       Date:  2021-03-22
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