| Literature DB >> 21287131 |
Radha Raman Pandey1, Chandrasekhar Kanduri.
Abstract
Recently, several lines of evidence have suggested that noncoding RNAs, which include both small and long noncoding RNAs (ncRNAs), contribute to a significant portion of the transcriptome in eukaryotic organisms. However, the functional significance of this wide-spread occurrence of ncRNAs, and in particular, the long ncRNAs (lncRNAs), for organismal development and differentiation is unclear. The available evidence from a subset of lncRNAs suggests that certain lncRNAs, and/or the act of their transcription, are involved in important biological functions at the transcriptional and posttranscriptional level. This chapter discusses the epigenetic and nonepigenetic mechanisms by which lncRNAs and/or their transcription are involved in the programming of various biological functions in model systems, from yeast to mammals.Entities:
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Year: 2011 PMID： 21287131 DOI： 10.1007/978-3-642-16502-3_1
Source DB: PubMed Journal: Prog Mol Subcell Biol ISSN： 0079-6484