Literature DB >> 21286700

Peroxisome proliferator activated receptor-alpha (PPARα) and PPAR gamma coactivator-1alpha (PGC-1α) regulation of cardiac metabolism in diabetes.

Jennifer G Duncan1.   

Abstract

Cardiovascular disease is a leading cause of mortality among patients with diabetes, and heart failure exists even in the absence of coronary disease. Myocardial metabolism is altered in the diabetic heart as a result of changes in substrate availability secondary to insulin resistance. The nuclear receptor peroxisome proliferator activated receptor-alpha (PPARα) and PPAR-gamma coactivator-1alpha (PGC-1α) play important roles in transcriptional regulation of myocardial metabolism and contribute significantly to the changes that occur in the diabetic heart. This review summarizes the role of PPARα and PGC-1α in myocardial metabolism in the normal heart and in the diabetic heart.

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Year:  2011        PMID： 21286700      PMCID： PMC3143064          DOI： 10.1007/s00246-011-9889-8

Source DB:  PubMed          Journal:  Pediatr Cardiol        ISSN： 0172-0643            Impact factor:   1.655


  61 in total

1.  Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha.

Authors:  Annika E Wallberg; Soichiro Yamamura; Sohail Malik; Bruce M Spiegelman; Robert G Roeder
Journal:  Mol Cell       Date:  2003-11       Impact factor: 17.970

Review 2.  Transcriptional regulatory circuits controlling mitochondrial biogenesis and function.

Authors:  Daniel P Kelly; Richard C Scarpulla
Journal:  Genes Dev       Date:  2004-02-15       Impact factor: 11.361

Review 3.  Biological control through regulated transcriptional coactivators.

Authors:  Bruce M Spiegelman; Reinhart Heinrich
Journal:  Cell       Date:  2004-10-15       Impact factor: 41.582

4.  A role for peroxisome proliferator-activated receptor alpha (PPARalpha ) in the control of cardiac malonyl-CoA levels: reduced fatty acid oxidation rates and increased glucose oxidation rates in the hearts of mice lacking PPARalpha are associated with higher concentrations of malonyl-CoA and reduced expression of malonyl-CoA decarboxylase.

Authors:  Fiona M Campbell; Ray Kozak; Alese Wagner; Judith Y Altarejos; Jason R B Dyck; Darrell D Belke; David L Severson; Daniel P Kelly; Gary D Lopaschuk
Journal:  J Biol Chem       Date:  2001-12-04       Impact factor: 5.157

5.  Peroxisome proliferator-activated receptor (PPAR) alpha and PPARbeta/delta, but not PPARgamma, modulate the expression of genes involved in cardiac lipid metabolism.

Authors:  Andries J Gilde; Karin A J M van der Lee; Peter H M Willemsen; Giulia Chinetti; Feike R van der Leij; Ger J van der Vusse; Bart Staels; Marc van Bilsen
Journal:  Circ Res       Date:  2003-02-06       Impact factor: 17.367

6.  Dexamethasone induction of hypertension and diabetes is PPAR-alpha dependent in LDL receptor-null mice.

Authors:  Carlos Bernal-Mizrachi; Sherry Weng; Chu Feng; Brian N Finck; Russell H Knutsen; Teresa C Leone; Trey Coleman; Robert P Mecham; Daniel P Kelly; Clay F Semenkovich
Journal:  Nat Med       Date:  2003-07-06       Impact factor: 53.440

Review 7.  Metabolic remodelling of the failing heart: the cardiac burn-out syndrome?

Authors:  Marc van Bilsen; Pascal J H Smeets; Andries J Gilde; Ger J van der Vusse
Journal:  Cardiovasc Res       Date:  2004-02-01       Impact factor: 10.787

8.  Cardiac-specific induction of the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha promotes mitochondrial biogenesis and reversible cardiomyopathy in a developmental stage-dependent manner.

Authors:  Laurie K Russell; Carolyn M Mansfield; John J Lehman; Attila Kovacs; Michael Courtois; Jeffrey E Saffitz; Denis M Medeiros; Maria L Valencik; John A McDonald; Daniel P Kelly
Journal:  Circ Res       Date:  2004-01-15       Impact factor: 17.367

9.  Cardiac mitochondrial damage and biogenesis in a chronic model of type 1 diabetes.

Authors:  Xia Shen; Shirong Zheng; Visith Thongboonkerd; Ming Xu; William M Pierce; Jon B Klein; Paul N Epstein
Journal:  Am J Physiol Endocrinol Metab       Date:  2004-07-27       Impact factor: 4.310

10.  Lipoprotein lipase (LpL) on the surface of cardiomyocytes increases lipid uptake and produces a cardiomyopathy.

Authors:  Hiroaki Yagyu; Guangping Chen; Masayoshi Yokoyama; Kumiko Hirata; Ayanna Augustus; Yuko Kako; Toru Seo; Yunying Hu; E Peer Lutz; Martin Merkel; André Bensadoun; Shunichi Homma; Ira J Goldberg
Journal:  J Clin Invest       Date:  2003-02       Impact factor: 14.808
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  22 in total

1.  Suppression of oxidative phosphorylation in mouse embryonic fibroblast cells deficient in apurinic/apyrimidinic endonuclease.

Authors:  Rangaswamy Suganya; Anirban Chakraborty; Sumitra Miriyala; Tapas K Hazra; Tadahide Izumi
Journal:  DNA Repair (Amst)       Date:  2015-01-16

2.  Resveratrol restores sirtuin 1 (SIRT1) activity and pyruvate dehydrogenase kinase 1 (PDK1) expression after hemorrhagic injury in a rat model.

Authors:  Bixi Jian; Shaolong Yang; Irshad H Chaudry; Raghavan Raju
Journal:  Mol Med       Date:  2014-03-13       Impact factor: 6.354

Review 3.  Diabetic cardiomyopathy: bench to bedside.

Authors:  Joel D Schilling; Douglas L Mann
Journal:  Heart Fail Clin       Date:  2012-08-09       Impact factor: 3.179

Review 4.  Insulin resistance: metabolic mechanisms and consequences in the heart.

Authors:  E Dale Abel; Karen M O'Shea; Ravichandran Ramasamy
Journal:  Arterioscler Thromb Vasc Biol       Date:  2012-09       Impact factor: 8.311

Review 5.  Cardiac dysfunction and oxidative stress in the metabolic syndrome: an update on antioxidant therapies.

Authors:  Olesya Ilkun; Sihem Boudina
Journal:  Curr Pharm Des       Date:  2013       Impact factor: 3.116

6.  Mitochondrial remodeling in mice with cardiomyocyte-specific lipid overload.

Authors:  Aly Elezaby; Aaron L Sverdlov; Vivian H Tu; Kanupriya Soni; Ivan Luptak; Fuzhong Qin; Marc Liesa; Orian S Shirihai; Jamie Rimer; Jean E Schaffer; Wilson S Colucci; Edward J Miller
Journal:  J Mol Cell Cardiol       Date:  2014-12-09       Impact factor: 5.000

Review 7.  The many roles of PGC-1α in muscle--recent developments.

Authors:  Mun Chun Chan; Zolt Arany
Journal:  Metabolism       Date:  2014-01-17       Impact factor: 8.694

8.  Activated peroxisomal fatty acid metabolism improves cardiac recovery in ischemia-reperfusion.

Authors:  Edgars Liepinsh; Elina Skapare; Janis Kuka; Marina Makrecka; Helena Cirule; Edijs Vavers; Eduards Sevostjanovs; Solveiga Grinberga; Osvalds Pugovics; Maija Dambrova
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2013-03-26       Impact factor: 3.000

Review 9.  Diabetic cardiomyopathy: molecular mechanisms, detrimental effects of conventional treatment, and beneficial effects of natural therapy.

Authors:  Brahmanaidu Parim; V V Sathibabu Uddandrao; Ganapathy Saravanan
Journal:  Heart Fail Rev       Date:  2019-03       Impact factor: 4.214

10.  Cardioprotection in the aging, diabetic heart: the loss of protective Akt signalling.

Authors:  Hannah J Whittington; Idris Harding; Clemency I M Stephenson; Robert Bell; Derek J Hausenloy; Mihaela M Mocanu; Derek M Yellon
Journal:  Cardiovasc Res       Date:  2013-05-30       Impact factor: 10.787
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