Literature DB >> 21286372

Induction of antitumor immunity by dendritic cells loaded with membrane-translocating mucin 1 Peptide antigen.

Saho Kobukai1, Gert-Jan Kremers, Jared G Cobb, Richard Baheza, Jingping Xie, Alex Kuley, Meiying Zhu, Wellington Pham.   

Abstract

To investigate the role of enhanced antigen presentation in dendritic cell (DC)-based immunotherapy. Here, we describe the development of a cell-penetrating mucin 1 (MUC1) antigen and its immunotherapeutic potential against tumors. After animal groups received two immunizations of MUC1-MPA(11)P-pulsed DCs, we observed a marked tumor regression compared with the mice treated with DCs alone or DCs pulsed with MUC1 peptide. We confirmed the migration and homing of DCs in the popliteal lymph node using magnetic resonance imaging during the study. In summary, enhanced antigen uptake using an MPA(11)P delivery molecule improves cell therapy.

Entities:  

Year:  2011        PMID： 21286372      PMCID： PMC3026404          DOI： 10.1593/tlo.10166

Source DB:  PubMed          Journal:  Transl Oncol        ISSN： 1936-5233            Impact factor:   4.243


  38 in total

1.  Developing a peptide-based near-infrared molecular probe for protease sensing.

Authors:  Wellington Pham; Yongdoo Choi; Ralph Weissleder; Ching-Hsuan Tung
Journal:  Bioconjug Chem       Date:  2004 Nov-Dec       Impact factor: 4.774

2.  Magnetic nanoparticles for imaging dendritic cells.

Authors:  Saho Kobukai; Richard Baheza; Jared G Cobb; Jack Virostko; Jingping Xie; Amelie Gillman; Dmitry Koktysh; Denny Kerns; Mark Does; John C Gore; Wellington Pham
Journal:  Magn Reson Med       Date:  2010-05       Impact factor: 4.668

3.  Introduction of soluble proteins into the MHC class I pathway by conjugation to an HIV tat peptide.

Authors:  D T Kim; D J Mitchell; D G Brockstedt; L Fong; G P Nolan; C G Fathman; E G Engleman; J B Rothbard
Journal:  J Immunol       Date:  1997-08-15       Impact factor: 5.422

Review 4.  Immune responses in the draining lymph nodes against cancer: implications for immunotherapy.

Authors:  Suyu Shu; Alistair J Cochran; Rong-Rong Huang; Donald L Morton; Holden T Maecker
Journal:  Cancer Metastasis Rev       Date:  2006-06       Impact factor: 9.264

5.  Development of a dendritic cell (DC)-based vaccine for patients with advanced colorectal cancer.

Authors:  N Rains; R J Cannan; W Chen; R S Stubbs
Journal:  Hepatogastroenterology       Date:  2001 Mar-Apr

6.  Dendritic cells in antitumor immune responses. I. Defective antigen presentation in tumor-bearing hosts.

Authors:  D I Gabrilovich; I F Ciernik; D P Carbone
Journal:  Cell Immunol       Date:  1996-05-25       Impact factor: 4.868

Review 7.  Dendritic cells: therapy and imaging.

Authors:  Wellington Pham; Saho Kobukai; Chie Hotta; John C Gore
Journal:  Expert Opin Biol Ther       Date:  2009-05       Impact factor: 4.388

8.  Increased expression of MUC1 in advanced pancreatic cancer.

Authors:  Yuji Hinoda; Yoshito Ikematsu; Michiko Horinochi; Shuji Sato; Kotaro Yamamoto; Tomoko Nakano; Mikiko Fukui; Yutaka Suehiro; Yuichiro Hamanaka; Yoshiro Nishikawa; Hideo Kida; Shinji Waki; Masaaki Oka; Kohzoh Imai; Suguru Yonezawa
Journal:  J Gastroenterol       Date:  2003       Impact factor: 7.527

Review 9.  Leukemic dendritic cells: potential for therapy and insights towards immune escape by leukemic blasts.

Authors:  M Mohty; D Olive; B Gaugler
Journal:  Leukemia       Date:  2002-11       Impact factor: 11.528

10.  Peptide-pulsed dendritic cells induce antigen-specific CTL-mediated protective tumor immunity.

Authors:  C M Celluzzi; J I Mayordomo; W J Storkus; M T Lotze; L D Falo
Journal:  J Exp Med       Date:  1996-01-01       Impact factor: 14.307
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  7 in total

1.  Dephosphorylation and biodistribution of 1-¹³C-phospholactate in vivo.

Authors:  Roman V Shchepin; Wellington Pham; Eduard Y Chekmenev
Journal:  J Labelled Comp Radiopharm       Date:  2014-07-03       Impact factor: 1.921

2.  Vaccine Development Against Leishmania donovani.

Authors:  Amrita Das; Nahid Ali
Journal:  Front Immunol       Date:  2012-05-15       Impact factor: 7.561

3.  Inactivated Sendai virus strain Tianjin, a novel genotype of Sendai virus, inhibits growth of murine colon carcinoma through inducing immune responses and apoptosis.

Authors:  Liying Shi; Jun Chen; Qiping Zhong; Mei Li; Peng Geng; Jianmin He; Zhe Han; Mingwei Sheng; Hua Tang
Journal:  J Transl Med       Date:  2013-09-05       Impact factor: 5.531

4.  Improved proliferation of antigen-specific cytolytic T lymphocytes using a multimodal nanovaccine.

Authors:  Bo Li; Michael Siuta; Vanessa Bright; Dmitry Koktysh; Brittany K Matlock; Megan E Dumas; Meiying Zhu; Alex Holt; Donald Stec; Shenglou Deng; Paul B Savage; Sebastian Joyce; Wellington Pham
Journal:  Int J Nanomedicine       Date:  2016-11-16

5.  Delivering Two Tumour Antigens Survivin and Mucin-1 on Virus-Like Particles Enhances Anti-Tumour Immune Responses.

Authors:  Katrin Campbell; Vivienne L Young; Braeden C Donaldson; Matthew J Woodall; Nicholas J Shields; Greg F Walker; Vernon K Ward; Sarah L Young
Journal:  Vaccines (Basel)       Date:  2021-05-06

6.  Convergent synthesis and evaluation of (18)F-labeled azulenic COX2 probes for cancer imaging.

Authors:  Donald D Nolting; Michael Nickels; Mohammed N Tantawy; James Y H Yu; Jingping Xie; Todd E Peterson; Brenda C Crews; Larry Marnett; John C Gore; Wellington Pham
Journal:  Front Oncol       Date:  2013-01-03       Impact factor: 6.244

Review 7.  MUC1-specific cytotoxic T lymphocytes in cancer therapy: induction and challenge.

Authors:  David Roulois; Marc Grégoire; Jean-François Fonteneau
Journal:  Biomed Res Int       Date:  2012-12-26       Impact factor: 3.411
  7 in total

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