Literature DB >> 2128587

Comparative effects of direct and indirect hydroxyl radical scavengers on traumatic brain oedema.

Y Ikeda1, D M Long.   

Abstract

The effects of dimethyl sulfoxide (DMSO) and dimethylthiourea (DMTU) and deferoxamine (DFO) were investigated in cats during a standard cortical freezing method for the production of vasogenic brain oedema. Hydroxyl radical scavenging activity was studied by electron spin resonance assay using DMPO as the trap. The hydroxyl radical spin adduct was extinguished by DFO and a large dose of DMTU. Evans blue dye extravasation was reduced in DFO and DMSO treated groups as well. DFO appears to be an effective agent for the prevention of cold induced oedema. DMSO and DMTU are direct hydroxyl radical scavengers. These studies suggest that scavenging the hydroxyl radicals has a beneficial effect in the treatment of traumatic brain oedema.

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Year:  1990        PMID： 2128587     DOI： 10.1007/978-3-7091-9115-6_25

Source DB:  PubMed          Journal:  Acta Neurochir Suppl (Wien)


  9 in total

1.  Deferoxamine attenuates iron-induced long-term neurotoxicity in rats with traumatic brain injury.

Authors:  Lijun Zhang; Rong Hu; Mei Li; Fei Li; Hui Meng; Gang Zhu; Jiangkai Lin; Hua Feng
Journal:  Neurol Sci       Date:  2012-04-27       Impact factor: 3.307

Review 2.  Effect of intratympanic dimethyl sulphoxide (DMSO) in an in vivo model of cisplatin-related ototoxicity.

Authors:  A Roldán-Fidalgo; A Trinidad; A Rodríguez-Valiente; J R García-Berrocal; I Millán; M J Coronado; R Ramírez-Camacho
Journal:  Eur Arch Otorhinolaryngol       Date:  2014-03-08       Impact factor: 2.503

3.  Cytotoxic effects of dimethyl sulphoxide (DMSO) on cochlear organotypic cultures.

Authors:  Weidong Qi; Dalian Ding; Richard J Salvi
Journal:  Hear Res       Date:  2007-12-15       Impact factor: 3.208

4.  Structure and regulation of the mDot1 gene, a mouse histone H3 methyltransferase.

Authors:  Wenzheng Zhang; Yoshihide Hayashizaki; Bruce C Kone
Journal:  Biochem J       Date:  2004-02-01       Impact factor: 3.857

5.  Magnetic resonance imaging assays for dimethyl sulfoxide effect on cancer vasculature.

Authors:  Clemens C Cyran; Barbara Sennino; Bundit Chaopathomkul; Yanjun Fu; Victor Rogut; David M Shames; Michael F Wendland; Donald M McDonald; Robert C Brasch
Journal:  Invest Radiol       Date:  2008-05       Impact factor: 6.016

6.  Exposure to DMSO during infancy alters neurochemistry, social interactions, and brain morphology in long-evans rats.

Authors:  Zachary Rabow; Taryn Morningstar; Megan Showalter; Hailey Heil; Krista Thongphanh; Sili Fan; Joanne Chan; Verónica Martínez-Cerdeño; Robert Berman; David Zagzag; Evgeny Nudler; Oliver Fiehn; Mirna Lechpammer
Journal:  Brain Behav       Date:  2021-04-10       Impact factor: 2.708

7.  Dimethyl sulfoxide promotes the multiple functions of the tumor suppressor HLJ1 through activator protein-1 activation in NSCLC cells.

Authors:  Chi-Chung Wang; Sheng-Yi Lin; Yi-Hua Lai; Ya-Jung Liu; Yuan-Lin Hsu; Jeremy J W Chen
Journal:  PLoS One       Date:  2012-04-17       Impact factor: 3.240

8.  The cytotoxic effects of dimethyl sulfoxide in mouse preimplantation embryos: a mechanistic study.

Authors:  Min-Hee Kang; Joydeep Das; Sangiliyandi Gurunathan; Hwan-Woo Park; Hyuk Song; Chankyu Park; Jin-Hoi Kim
Journal:  Theranostics       Date:  2017-10-17       Impact factor: 11.556

9.  Dimethyl Sulfoxide: A Bio-Friendly or Bio-Hazard Chemical? The Effect of DMSO in Human Fibroblast-like Synoviocytes.

Authors:  Manuel Gallardo-Villagrán; Lucie Paulus; David Yannick Leger; Bruno Therrien; Bertrand Liagre
Journal:  Molecules       Date:  2022-07-13       Impact factor: 4.927
  9 in total

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