OBJECTIVE: To evaluate pregnancy outcome in women with chronic kidney disease (CKD) or proteinuria in early pregnancy with concomitant risk for preeclampsia (PE). METHODS: Thirty-six women with CKD (Cr > 100 μmol/L at booking or Cr > 125 μmol/L prepregnancy or proteinuria ≥ 500 mg/24 hours at booking) and 30 women with proteinuria (≥2+) and known clinical risk for PE were enrolled at 14(+0) to 21(+6) weeks. Pregnancy outcomes were assessed. RESULTS: Women with mild CKD (prepregnancy Cr < 125 µmol/Cr > 100 µmol at booking; n = 22) had high rates of preeclampsia (40%), preterm delivery (<37 weeks' gestation; 54%), SGA infants (<10th adjusted centile; 64%)and perinatal death (5%). Women with moderate/severe CKD (prepregnancy creatinine > 125 µmol; n = 14) had poor perinatal outcomes: preterm delivery (86%) and perinatal death (14%). Women with proteinuria (≥2+) and concomitant risk of PE also had high rates of pre-eclampsia (60%), preterm delivery (40%), and SGA infants (27%). CONCLUSIONS: Pregnancy complications for women with CKD remain high. Women with risk factors for PE with proteinuria (≥2+) at booking are also high-risk.
OBJECTIVE: To evaluate pregnancy outcome in women with chronic kidney disease (CKD) or proteinuria in early pregnancy with concomitant risk for preeclampsia (PE). METHODS: Thirty-six women with CKD (Cr > 100 μmol/L at booking or Cr > 125 μmol/L prepregnancy or proteinuria ≥ 500 mg/24 hours at booking) and 30 women with proteinuria (≥2+) and known clinical risk for PE were enrolled at 14(+0) to 21(+6) weeks. Pregnancy outcomes were assessed. RESULTS: Women with mild CKD (prepregnancy Cr < 125 µmol/Cr > 100 µmol at booking; n = 22) had high rates of preeclampsia (40%), preterm delivery (<37 weeks' gestation; 54%), SGA infants (<10th adjusted centile; 64%)and perinatal death (5%). Women with moderate/severe CKD (prepregnancy creatinine > 125 µmol; n = 14) had poor perinatal outcomes: preterm delivery (86%) and perinatal death (14%). Women with proteinuria (≥2+) and concomitant risk of PE also had high rates of pre-eclampsia (60%), preterm delivery (40%), and SGA infants (27%). CONCLUSIONS: Pregnancy complications for women with CKD remain high. Women with risk factors for PE with proteinuria (≥2+) at booking are also high-risk.
Authors: Xiumei Hong; Avi Z Rosenberg; Boyang Zhang; Elizabeth Binns-Roemer; Victor David; Yiming Lv; Rebecca C Hjorten; Kimberly J Reidy; Teresa K Chen; Guoying Wang; Yuelong Ji; Claire L Simpson; Robert L Davis; Jeffrey B Kopp; Xiaobin Wang; Cheryl A Winkler Journal: Am J Kidney Dis Date: 2020-12-22 Impact factor: 11.072
Authors: K J Gray; V P Kovacheva; H Mirzakhani; A C Bjonnes; B Almoguera; M L Wilson; S A Ingles; C J Lockwood; H Hakonarson; T F McElrath; J C Murray; E R Norwitz; S A Karumanchi; B T Bateman; B J Keating; R Saxena Journal: BJOG Date: 2020-09-14 Impact factor: 6.531
Authors: Kate Bramham; Carlos E Poli-de-Figueiredo; Paul T Seed; Annette L Briley; Lucilla Poston; Andrew H Shennan; Lucy C Chappell Journal: PLoS One Date: 2013-10-10 Impact factor: 3.240