OBJECTIVE: The common polymorphism rs4994 [c. T387C, p. Trp64Arg (W64R)] of the lipolysis regulator beta-3-adrenergic receptor (ADRB3) was identified as a marker in the pathogenesis of hyperuricemia. As gout is characterized by elevated serum concentrations of uric acid, we investigated ADRB3 as a potential candidate for gout. METHODS: This was a prospective case-control study in a group of 421 male patients with gout and 312 gout-free male controls to genotype the single-nucleotide polymorphism rs4994 of ADRB3 gene. RESULTS: Our results showed that the C allele carrier confers a significantly higher risk for development of gout [chi-square = 4.91, df = 1, p = 0.027, OR 1.95 (adjusted by age, total cholesterol level, and body mass index), 95% CI 1.22-3.13 by dominant mode]. There was significantly higher uric acid level in carriers of the Arg64/Arg64 genotype in controls compared to non-carriers (480.5 mmol/l vs 315.0 mmol/l, respectively). CONCLUSION: ADRB3 rs4994 polymorphism is a potential candidate for the pathogenesis of gout in a male Chinese population.
OBJECTIVE: The common polymorphism rs4994 [c. T387C, p. Trp64Arg (W64R)] of the lipolysis regulator beta-3-adrenergic receptor (ADRB3) was identified as a marker in the pathogenesis of hyperuricemia. As gout is characterized by elevated serum concentrations of uric acid, we investigated ADRB3 as a potential candidate for gout. METHODS: This was a prospective case-control study in a group of 421 male patients with gout and 312 gout-free male controls to genotype the single-nucleotide polymorphism rs4994 of ADRB3 gene. RESULTS: Our results showed that the C allele carrier confers a significantly higher risk for development of gout [chi-square = 4.91, df = 1, p = 0.027, OR 1.95 (adjusted by age, total cholesterol level, and body mass index), 95% CI 1.22-3.13 by dominant mode]. There was significantly higher uric acid level in carriers of the Arg64/Arg64 genotype in controls compared to non-carriers (480.5 mmol/l vs 315.0 mmol/l, respectively). CONCLUSION:ADRB3 rs4994 polymorphism is a potential candidate for the pathogenesis of gout in a male Chinese population.
Authors: Tahzeeb Fatima; Sara Altaf; Amanda Phipps-Green; Ruth Topless; Tanya J Flynn; Lisa K Stamp; Nicola Dalbeth; Tony R Merriman Journal: Rheumatol Int Date: 2015-09-26 Impact factor: 2.631
Authors: Tahzeeb Fatima; Peter M Nilsson; Carl Turesson; Mats Dehlin; Nicola Dalbeth; Lennart T H Jacobsson; Meliha C Kapetanovic Journal: Arthritis Res Ther Date: 2020-10-16 Impact factor: 5.156