Literature DB >> 21284977

AMPK-dependent phosphorylation of ULK1 induces autophagy.

Mantong Zhao1, Daniel J Klionsky.   

Abstract

AMP-activated protein kinase (AMPK) is a highly conserved cellular energy sensor that plays a central role in metabolic homeostasis. A recent study in Science (Egan et al., 2011) identifies ULK1 as a substrate for AMPK phosphorylation, a modification required for selective autophagy of mitochondria and cell survival during starvation.
Copyright © 2011 Elsevier Inc. All rights reserved.

Entities:  

Year:  2011        PMID： 21284977      PMCID： PMC3056410          DOI： 10.1016/j.cmet.2011.01.009

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  10 in total

Review 1.  The molecular mechanism of mitochondria autophagy in yeast.

Authors:  Tomotake Kanki; Daniel J Klionsky
Journal:  Mol Microbiol       Date:  2010-02       Impact factor: 3.501

Review 2.  Eaten alive: a history of macroautophagy.

Authors:  Zhifen Yang; Daniel J Klionsky
Journal:  Nat Cell Biol       Date:  2010-09       Impact factor: 28.824

3.  The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis.

Authors:  Jiyong Liang; Shan H Shao; Zhi-Xiang Xu; Bryan Hennessy; Zhiyong Ding; Michelle Larrea; Seiji Kondo; Dan J Dumont; Jordan U Gutterman; Cheryl L Walker; Joyce M Slingerland; Gordon B Mills
Journal:  Nat Cell Biol       Date:  2007-01-21       Impact factor: 28.824

Review 4.  The role of the Atg1/ULK1 complex in autophagy regulation.

Authors:  Noboru Mizushima
Journal:  Curr Opin Cell Biol       Date:  2010-01-06       Impact factor: 8.382

5.  TSC2 mediates cellular energy response to control cell growth and survival.

Authors:  Ken Inoki; Tianqing Zhu; Kun-Liang Guan
Journal:  Cell       Date:  2003-11-26       Impact factor: 41.582

6.  The association of AMPK with ULK1 regulates autophagy.

Authors:  Jong Woo Lee; Sungman Park; Yoshinori Takahashi; Hong-Gang Wang
Journal:  PLoS One       Date:  2010-11-03       Impact factor: 3.240

7.  The LKB1-AMPK pathway: metabolism and growth control in tumour suppression.

Authors:  David B Shackelford; Reuben J Shaw
Journal:  Nat Rev Cancer       Date:  2009-08       Impact factor: 60.716

8.  AMPK phosphorylation of raptor mediates a metabolic checkpoint.

Authors:  Dana M Gwinn; David B Shackelford; Daniel F Egan; Maria M Mihaylova; Annabelle Mery; Debbie S Vasquez; Benjamin E Turk; Reuben J Shaw
Journal:  Mol Cell       Date:  2008-04-25       Impact factor: 17.970

9.  TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells.

Authors:  Griselda Herrero-Martín; Maria Høyer-Hansen; Celina García-García; Claudia Fumarola; Thomas Farkas; Abelardo López-Rivas; Marja Jäättelä
Journal:  EMBO J       Date:  2009-02-05       Impact factor: 11.598

10.  Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy.

Authors:  Daniel F Egan; David B Shackelford; Maria M Mihaylova; Sara Gelino; Rebecca A Kohnz; William Mair; Debbie S Vasquez; Aashish Joshi; Dana M Gwinn; Rebecca Taylor; John M Asara; James Fitzpatrick; Andrew Dillin; Benoit Viollet; Mondira Kundu; Malene Hansen; Reuben J Shaw
Journal:  Science       Date:  2010-12-23       Impact factor: 47.728
  10 in total
  59 in total

Review 1.  DNA damage and autophagy.

Authors:  Humberto Rodriguez-Rocha; Aracely Garcia-Garcia; Mihalis I Panayiotidis; Rodrigo Franco
Journal:  Mutat Res       Date:  2011-03-17       Impact factor: 2.433

2.  Translational control during endoplasmic reticulum stress beyond phosphorylation of the translation initiation factor eIF2α.

Authors:  Bo-Jhih Guan; Dawid Krokowski; Mithu Majumder; Christine L Schmotzer; Scot R Kimball; William C Merrick; Antonis E Koromilas; Maria Hatzoglou
Journal:  J Biol Chem       Date:  2014-03-19       Impact factor: 5.157

Review 3.  Myocardial autophagic energy stress responses--macroautophagy, mitophagy, and glycophagy.

Authors:  Lea M D Delbridge; Kimberley M Mellor; David J R Taylor; Roberta A Gottlieb
Journal:  Am J Physiol Heart Circ Physiol       Date:  2015-03-06       Impact factor: 4.733

4.  Yorkie Growth-Promoting Activity Is Limited by Atg1-Mediated Phosphorylation.

Authors:  Lauren K Tyra; Nilay Nandi; Charles Tracy; Helmut Krämer
Journal:  Dev Cell       Date:  2020-02-06       Impact factor: 12.270

5.  Modulation of glutamine metabolism by the PI(3)K-PKB-FOXO network regulates autophagy.

Authors:  Kristan E van der Vos; Pernilla Eliasson; Tassula Proikas-Cezanne; Stephin J Vervoort; Ruben van Boxtel; Marrit Putker; Iris J van Zutphen; Mario Mauthe; Sebastian Zellmer; Cornelieke Pals; Liesbeth P Verhagen; Marian J A Groot Koerkamp; A Koen Braat; Tobias B Dansen; Frank C Holstege; Rolf Gebhardt; Boudewijn M Burgering; Paul J Coffer
Journal:  Nat Cell Biol       Date:  2012-07-22       Impact factor: 28.824

Review 6.  Autophagy and its function in radiosensitivity.

Authors:  Yan Yang; Yuehua Yang; Xi Yang; Hongcheng Zhu; Qing Guo; Xiaochen Chen; Hao Zhang; Hongyan Cheng; Xinchen Sun
Journal:  Tumour Biol       Date:  2015-05-07

7.  Serine/Threonine Kinase Unc-51-like Kinase-1 (Ulk1) Phosphorylates the Co-chaperone Cell Division Cycle Protein 37 (Cdc37) and Thereby Disrupts the Stability of Cdc37 Client Proteins.

Authors:  Ran Li; Fengjie Yuan; Wan Fu; Luyao Zhang; Nan Zhang; Yanan Wang; Ke Ma; Xue Li; Lina Wang; Wei-Guo Zhu; Ying Zhao
Journal:  J Biol Chem       Date:  2017-01-10       Impact factor: 5.157

8.  High expression levels of unc-51-like kinase 1 as a predictor of poor prognosis in colorectal cancer.

Authors:  Yifeng Zou; Zexian Chen; Xiaowen He; Xiaosheng He; Xianrui Wu; Yufeng Chen; Xiaojian Wu; Jianping Wang; Ping Lan
Journal:  Oncol Lett       Date:  2015-06-24       Impact factor: 2.967

9.  Digitoxin Suppresses Human Cytomegalovirus Replication via Na+, K+/ATPase α1 Subunit-Dependent AMP-Activated Protein Kinase and Autophagy Activation.

Authors:  Rupkatha Mukhopadhyay; Rajkumar Venkatadri; Jenny Katsnelson; Ravit Arav-Boger
Journal:  J Virol       Date:  2018-02-26       Impact factor: 5.103

Review 10.  Adiponectin signaling in the liver.

Authors:  Terry P Combs; Errol B Marliss
Journal:  Rev Endocr Metab Disord       Date:  2014-06       Impact factor: 6.514
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