Literature DB >> 21284671

Acetaldehyde burst protection of ADH1B*2 against alcoholism: an additional hormesis protection against esophageal cancers following alcohol consumption?

Yedy Israel1, Mario Rivera-Meza, María Elena Quintanilla, Amalia Sapag, Lutske Tampier.   

Abstract

This account of recent work presented at the 4th International Symposium on Alcohol Pancreatitis and Cirrhosis reports animal studies aimed at determining the role of the "acetaldehyde burst," generated shortly upon ethanol intake, as the mechanism of protection against alcoholism conferred by the ADH1B*2 polymorphism. Literature studies discussed suggest an additional role of the acetaldehyde burst on the paradoxical (hormesis) protection of the ADH1B*2 polymorphism against esophageal cancers in alcoholics.
Copyright © 2011 by the Research Society on Alcoholism.

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Year:  2011        PMID： 21284671      PMCID： PMC3142558          DOI： 10.1111/j.1530-0277.2010.01403.x

Source DB:  PubMed          Journal:  Alcohol Clin Exp Res        ISSN： 0145-6008            Impact factor:   3.455


  38 in total

1.  Interaction between the functional polymorphisms of the alcohol-metabolism genes in protection against alcoholism.

Authors:  C C Chen; R B Lu; Y C Chen; M F Wang; Y C Chang; T K Li; S J Yin
Journal:  Am J Hum Genet       Date:  1999-09       Impact factor: 11.025

2.  Evidence for beneficial low level radiation effects and radiation hormesis.

Authors:  L E Feinendegen
Journal:  Br J Radiol       Date:  2005-01       Impact factor: 3.039

3.  Do alcohol-metabolizing enzyme gene polymorphisms increase the risk of alcoholism and alcoholic liver disease?

Authors:  Elias Zintzaras; Ioannis Stefanidis; Mauro Santos; Francesc Vidal
Journal:  Hepatology       Date:  2006-02       Impact factor: 17.425

Review 4.  Alcohol-related genes: contributions from studies with genetically engineered mice.

Authors:  John C Crabbe; Tamara J Phillips; R Adron Harris; Michael A Arends; George F Koob
Journal:  Addict Biol       Date:  2006-09       Impact factor: 4.280

Review 5.  The UChA and UChB rat lines: metabolic and genetic differences influencing ethanol intake.

Authors:  María E Quintanilla; Yedy Israel; Amalia Sapag; Lutske Tampier
Journal:  Addict Biol       Date:  2006-09       Impact factor: 4.280

6.  Polymorphisms of ethanol metabolizing enzyme genes and alcoholism.

Authors:  S Higuchi
Journal:  Alcohol Alcohol Suppl       Date:  1994

7.  Evidence for an important role of alcohol- and aldehyde-metabolizing genes in cancers of the upper aerodigestive tract.

Authors:  Mia Hashibe; Paolo Boffetta; David Zaridze; Oxana Shangina; Neonila Szeszenia-Dabrowska; Dana Mates; Vladimir Janout; Eleonóra Fabiánová; Vladimir Bencko; Norman Moullan; Amelie Chabrier; Rayjean Hung; Janet Hall; Federico Canzian; Paul Brennan
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2006-04       Impact factor: 4.254

8.  Involvement of genetic polymorphism of alcohol and aldehyde dehydrogenases in individual variation of alcohol metabolism.

Authors:  Y Mizoi; K Yamamoto; Y Ueno; T Fukunaga; S Harada
Journal:  Alcohol Alcohol       Date:  1994-11       Impact factor: 2.826

9.  Mechanism of protection against alcoholism by an alcohol dehydrogenase polymorphism: development of an animal model.

Authors:  Mario Rivera-Meza; María Elena Quintanilla; Lutske Tampier; Casilda V Mura; Amalia Sapag; Yedy Israel
Journal:  FASEB J       Date:  2009-08-26       Impact factor: 5.191

Review 10.  Alcohol and all-cause mortality: an overview.

Authors:  J Rehm; S Bondy
Journal:  Novartis Found Symp       Date:  1998
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  1 in total

1.  Reduction of ethanol consumption in alcohol-preferring rats by dual expression gene transfer.

Authors:  Mario Rivera-Meza; María Elena Quintanilla; Lutske Tampier
Journal:  Alcohol Alcohol       Date:  2012-01-02       Impact factor: 2.826
  1 in total

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