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Literature DB >> 21284666

The unfolding web of innate immune dysregulation in alcoholic liver injury.

G Szabo¹, P Mandrekar, J Petrasek, D Catalano.

Abstract

Inflammatory cell and cytokine cascade activation is present in humans with alcoholic liver disease as well as in animal models of alcohol-induced liver damage. Gut-derived lipopolysaccharide (LPS), a ligand of the Toll-like receptor 4 (TLR4), plays a central role in triggering and maintaining activation of Kupffer cells in alcoholic hepatitis. In this mini-review, we describe molecular mechanisms that lead to increased inflammatory cell activation by alcohol and LPS and discuss the mechanism for activation in alcohol-exposed macrophages. In alcohol-induced liver disease we discuss the role of MyD88-independent but IRF3-mediated TLR4 signaling in alcohol-related liver inflammation and liver damage.

Entities: Chemical Disease Gene Species

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Year: 2011 PMID： 21284666 PMCID： PMC3742381 DOI： 10.1111/j.1530-0277.2010.01398.x

Source DB: PubMed Journal: Alcohol Clin Exp Res ISSN： 0145-6008 Impact factor: 3.455

38 in total

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6. Rapid up-regulation of IRAK-M expression following a second endotoxin challenge in human monocytes and in monocytes isolated from septic patients.

Authors: Pedro Escoll; Carlos del Fresno; Lourdes García; Gema Vallés; Manuel J Lendínez; Francisco Arnalich; Eduardo López-Collazo
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Authors: Laura E Nagy
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Authors: Kelly A Nordyke Messingham; Douglas E Faunce; Elizabeth J Kovacs
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10. Dysregulation of LPS-induced Toll-like receptor 4-MyD88 complex formation and IL-1 receptor-associated kinase 1 activation in endotoxin-tolerant cells.

Authors: Andrei E Medvedev; Arnd Lentschat; Larry M Wahl; Douglas T Golenbock; Stefanie N Vogel
Journal: J Immunol Date: 2002-11-01 Impact factor: 5.422

39 in total

Review 10. Gut microbiota in non-alcoholic fatty liver disease and alcohol-related liver disease: Current concepts and perspectives.

Authors: Juan P Arab; Marco Arrese; Vijay H Shah
Journal: Hepatol Res Date: 2020-01-13 Impact factor: 4.288

The unfolding web of innate immune dysregulation in alcoholic liver injury.

1. Toll-like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in mice.

Review 2. Effect of alcohol consumption on the gut.

Review 3. The feeding of alcohol in liquid diets: two decades of applications and 1982 update.

4. Alcoholic liver injury: experimental models in rats and baboons.

5. Reduced early alcohol-induced liver injury in CD14-deficient mice.

6. Rapid up-regulation of IRAK-M expression following a second endotoxin challenge in human monocytes and in monocytes isolated from septic patients.

7. Alcohol and malnutrition in the pathogenesis of liver disease..

Review 8. Recent insights into the role of the innate immune system in the development of alcoholic liver disease.

Review 9. Alcohol, injury, and cellular immunity.

10. Dysregulation of LPS-induced Toll-like receptor 4-MyD88 complex formation and IL-1 receptor-associated kinase 1 activation in endotoxin-tolerant cells.

1. Effects of Clostridium difficile infection in patients with alcoholic hepatitis.

2. Dietary saturated fatty acids reduce hepatic lipid accumulation but induce fibrotic change in alcohol-fed rats.

3. Deletion of tumor progression locus 2 attenuates alcohol-induced hepatic inflammation.

4. Adipose tissue-liver axis in alcoholic liver disease.

Review 5. Metabolic regulation of inflammasomes in inflammation.

Review 6. Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development.

7. Alcoholic liver disease - Hepatocellular carcinoma transformation.

8. MicroRNAs in Liver Disease: Bench to Bedside.

Review 9. Severe alcoholic hepatitis-current concepts, diagnosis and treatment options.

Review 10. Gut microbiota in non-alcoholic fatty liver disease and alcohol-related liver disease: Current concepts and perspectives.