Literature DB >> 2128450

Studies on 1,2,3-triazole derivatives as in vitro inhibitors of prostaglandin synthesis.

G Biagi1, G Dell'Omodarme, M Ferretti, I Giorgi, O Livi, V Scartoni, E Tiscione.   

Abstract

This paper reports some new structural modifications (branching and lengthening of alkanoic substituent, increase of heterocycle-carboxylate distance) on 1,2,3-triazole derivative 1, a potent in vitro inhibitor of prostaglandin synthesis, and their influence on enzyme activity. Regarding the structural relationship between 1 and Dazoxiben, a selective thromboxane-synthetase inhibitor, the preparation and activity of some Dazoxiben analogs bearing different heterocycles, are also described.

Entities:  

Mesh：

Substances：

Year:  1990        PMID： 2128450

Source DB:  PubMed          Journal:  Farmaco        ISSN： 0014-827X


  3 in total

1.  Design and synthesis of substituted (1-(benzyl)-1H-1,2,3-triazol-4-yl)(piperazin-1-yl)methanone conjugates: study on their apoptosis inducing ability and tubulin polymerization inhibition.

Authors:  Kesari Lakshmi Manasa; Sowjanya Thatikonda; Dilep Kumar Sigalapalli; Sowmya Vuppaladadium; Ganthala Parimala Devi; Chandraiah Godugu; Mallika Alvala; Narayana Nagesh; Bathini Nagendra Babu
Journal:  RSC Med Chem       Date:  2020-09-08

2.  Design, synthesis, molecular-docking and antimycobacterial evaluation of some novel 1,2,3-triazolyl xanthenones.

Authors:  Gudikadi Linga Goud; Seela Ramesh; Dongamanti Ashok; Vummenthala Prabhakar Reddy; Perumal Yogeeswari; Dharmarajan Sriram; Balabadra Saikrishna; Vijjulatha Manga
Journal:  Medchemcomm       Date:  2017-01-03       Impact factor: 3.597

3.  Design, Synthesis, and the Biological Evaluation of a New Series of Acyclic 1,2,3-Triazole Nucleosides.

Authors:  Iwona E Głowacka; Graciela Andrei; Dominique Schols; Robert Snoeck; Katarzyna Gawron
Journal:  Arch Pharm (Weinheim)       Date:  2017-08-01       Impact factor: 3.751
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.