Literature DB >> 2128302

Immune activation and decreased tryptophan in patients with HIV-1 infection.

D Fuchs1, A Forsman, L Hagberg, M Larsson, G Norkrans, G Reibnegger, E R Werner, H Wachter.   

Abstract

We compared tryptophan, neopterin, and interferon-gamma (IFN-gamma) concentrations in serum and cerebrospinal fluid (CSF) of 22 patients with human immunodeficiency virus type 1 (HIV-1) infection. Tryptophan levels were found to be decreased in CSF and serum of patients whereas neopterin levels in CSF and serum and serum IFN-gamma concentrations were increased compared to healthy HIV-1 seronegatives. Tryptophan concentrations correlated negatively to neopterin concentrations, and serum neopterin concentrations correlated positively to IFN-gamma concentrations. Thus, decrease of tryptophan levels is associated with chronic immune stimulation in patients with HIV-1 infection. From the data it appears that reduced tryptophan in patients may result from induction of indoleamine (2,3)-dioxygenase by IFN-gamma.

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Year:  1990        PMID： 2128302     DOI： 10.1089/jir.1990.10.599

Source DB:  PubMed          Journal:  J Interferon Res        ISSN： 0197-8357


  35 in total

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2.  L-Tryptophan: Biochemical, nutritional and pharmacological aspects.

Authors:  E L Sainio; K Pulkki; S N Young
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4.  Tryptophan degradation is associated with risk-taking propensity in methamphetamine users with treated HIV infection.

Authors:  Jared Lee; Ji-Young Lee; Christina S Meade; Michael Cohn; Antonio Chahine; Samantha E Dilworth; Jessica F Magidson; Hetta Gouse; Dietmar Fuchs; Adam W Carrico
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5.  Reduced type 1 and type 2 cytokines in antiviral memory T helper function among women coinfected with HIV and HCV.

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6.  HIV inhibits CD4+ T-cell proliferation by inducing indoleamine 2,3-dioxygenase in plasmacytoid dendritic cells.

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Review 9.  Antioxidants, inflammation and cardiovascular disease.

Authors:  Harald Mangge; Kathrin Becker; Dietmar Fuchs; Johanna M Gostner
Journal:  World J Cardiol       Date:  2014-06-26

10.  Dysbiosis of the gut microbiota is associated with HIV disease progression and tryptophan catabolism.

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Journal:  Sci Transl Med       Date:  2013-07-10       Impact factor: 17.956
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