BACKGROUND: It was recently confirmed that the antifungal agent ciclopirox olamine inhibits Wnt/beta catenin signaling in myeloma. Piroctone olamine (PO) has very similar chemical features to ciclopirox olamine. MATERIALS AND METHODS: This study investigated the antitumor effect of PO in vitro and in vivo in a murine myeloma model. RESULTS: PO demonstrated a major apoptotic activity in various human and murine myeloma and lymphoma cell lines, as well as in human primary cells. In vivo, tumor growth, as well as overall survival, was significantly reduced in mice treated with PO as compared to untreated mice. Interestingly, concerning tumor growth and survival of the animals, a significant additive effect was seen by the combination of lenalidomide plus PO as compared to single application. CONCLUSION: These results reveal a significant selective induction of apoptosis by PO and suggest a significant in vivo effect against myeloma.
BACKGROUND: It was recently confirmed that the antifungal agent ciclopirox olamine inhibits Wnt/beta catenin signaling in myeloma. Piroctone olamine (PO) has very similar chemical features to ciclopirox olamine. MATERIALS AND METHODS: This study investigated the antitumor effect of PO in vitro and in vivo in a murinemyeloma model. RESULTS:PO demonstrated a major apoptotic activity in various human and murinemyeloma and lymphoma cell lines, as well as in human primary cells. In vivo, tumor growth, as well as overall survival, was significantly reduced in mice treated with PO as compared to untreated mice. Interestingly, concerning tumor growth and survival of the animals, a significant additive effect was seen by the combination of lenalidomide plus PO as compared to single application. CONCLUSION: These results reveal a significant selective induction of apoptosis by PO and suggest a significant in vivo effect against myeloma.
Authors: Hae Jeong Youn; Soo Young Kim; Minji Park; Won Hee Jung; Yang Won Lee; Yong Beom Choe; Kyu Joong Ahn Journal: Ann Dermatol Date: 2016-11-23 Impact factor: 1.444
Authors: Noureddine Halla; Isabel P Fernandes; Sandrina A Heleno; Patrícia Costa; Zahia Boucherit-Otmani; Kebir Boucherit; Alírio E Rodrigues; Isabel C F R Ferreira; Maria Filomena Barreiro Journal: Molecules Date: 2018-06-28 Impact factor: 4.411
Authors: Fabíola Maria Marques do Couto; Silene Carneiro do Nascimento; Silvio Francisco Pereira Júnior; Vanessa Karina Alves da Silva; André Ferraz Goiana Leal; Rejane Pereira Neves Journal: Springerplus Date: 2016-04-16