| Literature DB >> 21282420 |
M Cuenca-Estrella1, A Gomez-Lopez, I Cuesta, O Zaragoza, E Mellado, J L Rodriguez-Tudela.
Abstract
A total of 4,226 Spanish clinical isolates of Candida spp. were analyzed to assess resistance to voriconazole according to breakpoints established by the European Committee for Antimicrobial Susceptibility Testing (where susceptibility [S] to voriconazole corresponds to a MIC of ≤ 0.12 mg/liter). Resistance was uncommon among Candida albicans (5%), C. parapsilosis (1.2%), and C. tropicalis (11%) isolates. Voriconazole MICs of >0.12 mg/liter were more frequent among Candida glabrata and C. krusei isolates. A significant percentage of voriconazole-resistant strains came from oropharyngeal infections and exhibited high MICs of other azoles.Entities:
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Year: 2011 PMID: 21282420 PMCID: PMC3067132 DOI: 10.1128/AAC.01757-10
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191