| Literature DB >> 21282041 |
Priscila Freitas-Lima1, Veriano Alexandre, Leonardo Regis Leira Pereira, Fausto Feletti, Emilio Perucca, Americo Ceiki Sakamoto.
Abstract
To assess whether levetiracetam elimination is influenced by enzyme inducing antiepileptic drugs (EIAEDs), serum levetiracetam levels were determined at frequent intervals after a single oral 1000mg dose in 15 subjects co-medicated with EIAEDs and 15 matched controls. The EIAED group showed a higher levetiracetam oral clearance (p=0.01) and a shorter half-life (p=0.02) than controls. Although the magnitude of interaction is relatively modest, it could have clinical significance for some patients.Entities:
Mesh：
Substances：
Year: 2011 PMID： 21282041 DOI： 10.1016/j.eplepsyres.2011.01.007
Source DB: PubMed Journal: Epilepsy Res ISSN： 0920-1211 Impact factor: 3.045