| Literature DB >> 21281527 |
S De1, D Pan, A K Bera, V Sreevatsava, S Bandyopadhyay, D Chaudhuri, S Kumar, T Rana, S Das, S K Das, V V Suryanaryana, M Norjit Singh, D Bhattacharya.
Abstract
The present study describes the activity of a nanomaterial on protoscoleces of Echinococcus granulosus, which exhibited morphological changes and apoptosis. Apoptotic changes were deduced on the basis of effector caspase activation and nucleosomal laddering. Invaginated protoscoleces maintained in vitro became evaginated and had hooks, presumptive suckers and stalks. Degenerative changes of protoscoleces were evidenced after treatment with praziquantel and nano-combination. Protoscoleces treated with praziquantel had distinct attestation of necrosis and nano-combination-treated protoscoleces had signatures of apoptosis.Entities:
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Year: 2011 PMID： 21281527 DOI： 10.1017/S0022149X10000908
Source DB: PubMed Journal: J Helminthol ISSN： 0022-149X Impact factor: 2.170