OBJECTIVE: Mosquito-borne alphaviruses such as chikungunya virus, o'nyong-nyong virus, and Ross River virus (RRV) cause sporadic, sometimes large, outbreaks of rheumatic disease worldwide. This study was designed to test the effect of treating RRV-induced arthritis using the anti-tumor necrosis factor (anti-TNF) drug etanercept in a mouse model of rheumatic disease. METHODS: Mice were infected with RRV and treated with etanercept. Weight gain was measured, tissue viral titers were determined, and histologic changes in muscle and joint tissues were assessed. RESULTS: RRV-infected mice treated with etanercept showed decreased weight gain, higher viral titers in muscle, joints, and blood, and more tissue damage and inflammatory cell recruitment than RRV-infected mice without treatment. CONCLUSION: Anti-TNF therapy is unlikely to be useful in treating alphaviral arthritides. During alphaviral epidemics, careful monitoring of patients being treated with anti-TNF agents may be warranted.
OBJECTIVE: Mosquito-borne alphaviruses such as chikungunya virus, o'nyong-nyong virus, and Ross River virus (RRV) cause sporadic, sometimes large, outbreaks of rheumatic disease worldwide. This study was designed to test the effect of treating RRV-induced arthritis using the anti-tumornecrosis factor (anti-TNF) drug etanercept in a mouse model of rheumatic disease. METHODS:Mice were infected with RRV and treated with etanercept. Weight gain was measured, tissue viral titers were determined, and histologic changes in muscle and joint tissues were assessed. RESULTS:RRV-infectedmice treated with etanercept showed decreased weight gain, higher viral titers in muscle, joints, and blood, and more tissue damage and inflammatory cell recruitment than RRV-infectedmice without treatment. CONCLUSION: Anti-TNF therapy is unlikely to be useful in treating alphaviral arthritides. During alphaviral epidemics, careful monitoring of patients being treated with anti-TNF agents may be warranted.
Authors: Jonathan J Miner; Lindsey E Cook; Jun P Hong; Amber M Smith; Justin M Richner; Raeann M Shimak; Alissa R Young; Kristen Monte; Subhajit Poddar; James E Crowe; Deborah J Lenschow; Michael S Diamond Journal: Sci Transl Med Date: 2017-02-01 Impact factor: 17.956
Authors: Matthew D McGeough; Alexander Wree; Maria E Inzaugarat; Ariela Haimovich; Casey D Johnson; Carla A Peña; Raphaela Goldbach-Mansky; Lori Broderick; Ariel E Feldstein; Hal M Hoffman Journal: J Clin Invest Date: 2017-11-13 Impact factor: 14.808
Authors: Yee Suan Poo; Penny A Rudd; Joy Gardner; Jane A C Wilson; Thibaut Larcher; Marie-Anne Colle; Thuy T Le; Helder I Nakaya; David Warrilow; Richard Allcock; Helle Bielefeldt-Ohmann; Wayne A Schroder; Alexander A Khromykh; José A Lopez; Andreas Suhrbier Journal: PLoS Negl Trop Dis Date: 2014-12-04
Authors: Jane A C Wilson; Natalie A Prow; Wayne A Schroder; Jonathan J Ellis; Helen E Cumming; Linden J Gearing; Yee Suan Poo; Adam Taylor; Paul J Hertzog; Francesca Di Giallonardo; Linda Hueston; Roger Le Grand; Bing Tang; Thuy T Le; Joy Gardner; Suresh Mahalingam; Pierre Roques; Phillip I Bird; Andreas Suhrbier Journal: PLoS Pathog Date: 2017-02-16 Impact factor: 6.823
Authors: Violet R Mukaro; Alex Quach; Michelle E Gahan; Bernadette Boog; Zhi H Huang; Xiuhui Gao; Carol Haddad; Suresh Mahalingam; Charles S Hii; Antonio Ferrante Journal: Nat Commun Date: 2018-04-10 Impact factor: 14.919