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Literature DB >> 21278905

Regulation of mitochondrial processes: a target for heart failure.

Suresh Selvaraj Palaniyandi¹, Xin Qi, Gouri Yogalingam, Julio Cesar Batista Ferreira, Daria Mochly-Rosen.

Abstract

Cardiac mitochondria, the main source of energy as well as free radicals, are vital organelles for normal functioning of the heart. Mitochondrial number, structure, turnover and function are regulated by processes such as mitochondrial protein quality control, mitochondrial fusion and fission and mitophagy. Recent studies suggest that abnormal changes in these mitochondrial regulatory processes may contribute to the pathology of heart failure (HF). Here we discuss these processes and their potential as therapeutic targets.

Entities: Chemical Disease Gene Mutation Species

Year: 2010 PMID： 21278905 PMCID： PMC3026286 DOI： 10.1016/j.ddmec.2010.07.002

Source DB: PubMed Journal: Drug Discov Today Dis Mech ISSN： 1740-6765

61 in total

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Authors: Heiko Bugger; Michael Schwarzer; Dong Chen; Andrea Schrepper; Paulo A Amorim; Maria Schoepe; T Dung Nguyen; Friedrich W Mohr; Oleh Khalimonchuk; Bart C Weimer; Torsten Doenst
Journal: Cardiovasc Res Date: 2009-10-19 Impact factor: 10.787

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Authors: J Schaper; R Froede; S Hein; A Buck; H Hashizume; B Speiser; A Friedl; N Bleese
Journal: Circulation Date: 1991-02 Impact factor: 29.690

17 in total

Review 1. Nitroglycerin use in myocardial infarction patients.

Authors: Julio C B Ferreira; Daria Mochly-Rosen
Journal: Circ J Date: 2011-11-01 Impact factor: 2.993

2. A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity.

Authors: Xin Qi; Nir Qvit; Yu-Chin Su; Daria Mochly-Rosen
Journal: J Cell Sci Date: 2012-12-13 Impact factor: 5.285

Review 3. Disruption of mitochondrial quality control in peripheral artery disease: New therapeutic opportunities.

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Journal: Pharmacol Res Date: 2016-11-19 Impact factor: 7.658

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Authors: José Marín-García; Alexander T Akhmedov; Gordon W Moe
Journal: Heart Fail Rev Date: 2013-07 Impact factor: 4.214

5. Aldehydic load and aldehyde dehydrogenase 2 profile during the progression of post-myocardial infarction cardiomyopathy: benefits of Alda-1.

Authors: Katia M S Gomes; Luiz R G Bechara; Vanessa M Lima; Márcio A C Ribeiro; Juliane C Campos; Paulo M Dourado; Alicia J Kowaltowski; Daria Mochly-Rosen; Julio C B Ferreira
Journal: Int J Cardiol Date: 2014-10-23 Impact factor: 4.164

6. Molecular signaling pathways in right ventricular impairment of adult patients after tetralogy of Fallot repair.

Authors: Kathrin Pollmann; Sarala Raj Murthi; Damir Kračun; Thomas Schwarzmayr; Andreas Petry; Julie Cleuziou; Jürgen Hörer; Mathieu Klop; Peter Ewert; Agnes Görlach; Cordula Maria Wolf
Journal: Cardiovasc Diagn Ther Date: 2021-12

7. Aldehyde dehydrogenase 2 activation in heart failure restores mitochondrial function and improves ventricular function and remodelling.

Authors: Katia M S Gomes; Juliane C Campos; Luiz R G Bechara; Bruno Queliconi; Vanessa M Lima; Marie-Helene Disatnik; Paulo Magno; Che-Hong Chen; Patricia C Brum; Alicia J Kowaltowski; Daria Mochly-Rosen; Julio C B Ferreira
Journal: Cardiovasc Res Date: 2014-05-09 Impact factor: 10.787