| Literature DB >> 21276449 |
Jin-Song Gao1, Yingjie Zhang, Xiaoli Tang, Lynne D Tucker, Patrick M Tarwater, Peter J Quesenberry, Isidore Rigoutsos, Bharat Ramratnam.
Abstract
MicroRNA profiling of diseased/non-diseased tissue has identified expression signatures associated with a wide range of pathogenic conditions including malignancy. For example, colon cancer is associated with the under expression of miRNA-143 yet the molecular etiology of under expression is unknown. The K-Ras oncogene is a target of miRNA-143. Here, we show that the ecotropic viral integration site 1 oncoprotein (Evi1) is a transcriptional suppressor of the miRNA-143 gene. We find an indirect relationship between miRNA-143 and Evi1 expression. A complex molecular axis linking Evi1, miRNA-143 is operational in human colon cancer.Entities:
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Year: 2011 PMID： 21276449 PMCID： PMC3440864 DOI： 10.1016/j.febslet.2011.01.033
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124