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Literature DB >> 21276004

The role of STAT5 in the development, function, and transformation of B and T lymphocytes.

Lynn M Heltemes-Harris¹, Mark J L Willette, Kieng B Vang, Michael A Farrar.

Abstract

The transcription factor signal transducer and activator of transcription 5 (STAT5) is activated by a number of cytokine and growth hormone receptors and plays a key role in the development and function of many organ systems. In this review, we focus on recent discoveries about the role of STAT5 in the development and function of B and T lymphocytes. Of particular interest is the growing appreciation for the function of STAT5 as a transcriptional repressor. Finally, we discuss recent discoveries about the role of STAT5 in transformation of B and T lymphocytes.

Entities: Gene

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Year: 2011 PMID： 21276004 DOI： 10.1111/j.1749-6632.2010.05907.x

Source DB: PubMed Journal: Ann N Y Acad Sci ISSN： 0077-8923 Impact factor: 5.691

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Cited

17 in total

1. Turning transcription on or off with STAT5: when more is less.

Authors: Michael A Farrar; Lynn M Heltemes Harris
Journal: Nat Immunol Date: 2011-11-16 Impact factor: 25.606

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Journal: J Cereb Blood Flow Metab Date: 2011-12-14 Impact factor: 6.200

3. The Tetraspanin CD53 Regulates Early B Cell Development by Promoting IL-7R Signaling.

Authors: Zev J Greenberg; Darlene A Monlish; Rachel L Bartnett; Yihu Yang; Guomin Shen; Weikai Li; Jeffrey J Bednarski; Laura G Schuettpelz
Journal: J Immunol Date: 2019-11-20 Impact factor: 5.422

4. A Tunable Diffusion-Consumption Mechanism of Cytokine Propagation Enables Plasticity in Cell-to-Cell Communication in the Immune System.

Authors: Alon Oyler-Yaniv; Jennifer Oyler-Yaniv; Benjamin M Whitlock; Zhiduo Liu; Ronald N Germain; Morgan Huse; Grégoire Altan-Bonnet; Oleg Krichevsky
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5. STAT5-mediated expression of oncogenic miR-155 in cutaneous T-cell lymphoma.

Authors: Katharina L Kopp; Ulrik Ralfkiaer; Lise Mette R Gjerdrum; Rikke Helvad; Ida H Pedersen; Thomas Litman; Lars Jønson; Peter H Hagedorn; Thorbjørn Krejsgaard; Robert Gniadecki; Charlotte M Bonefeld; Lone Skov; Carsten Geisler; Mariusz A Wasik; Elisabeth Ralfkiaer; Niels Ødum; Anders Woetmann
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6. Sialoadhesin ligand expression identifies a subset of CD4+Foxp3- T cells with a distinct activation and glycosylation profile.

Authors: Dana Kidder; Hannah E Richards; Hermann J Ziltener; Oliver A Garden; Paul R Crocker
Journal: J Immunol Date: 2013-02-13 Impact factor: 5.422

The role of STAT5 in the development, function, and transformation of B and T lymphocytes.

1. Turning transcription on or off with STAT5: when more is less.

2. Effects of gender on gene expression in the blood of ischemic stroke patients.

3. The Tetraspanin CD53 Regulates Early B Cell Development by Promoting IL-7R Signaling.

4. A Tunable Diffusion-Consumption Mechanism of Cytokine Propagation Enables Plasticity in Cell-to-Cell Communication in the Immune System.

5. STAT5-mediated expression of oncogenic miR-155 in cutaneous T-cell lymphoma.

6. Sialoadhesin ligand expression identifies a subset of CD4+Foxp3- T cells with a distinct activation and glycosylation profile.

7. Ebf1 and c-Myb repress rag transcription downstream of Stat5 during early B cell development.

Review 8. Role of intracellular signaling pathways and their inhibitors in the treatment of inflammation.

9. Network-based functional enrichment.

10. Fms-like tyrosine kinase 3 ligand controls formation of regulatory T cells in autoimmune arthritis.