Literature DB >> 21275598

Leber's hereditary optic neuropathy precipitated by tadalafil use for erectile dysfunction.

Kurt Spiteri Cornish1, Christopher Barras.   

Abstract

Leber's hereditary optic neuropathy (LHON) is an inherited condition leading to bilateral centrocaecal scotoma. Phosphodiesterase type-5 (PDE5) inhibitors such as tadalafil are widely used for male erectile dysfunction. We present a case of a middle-aged male whose LHON presented acutely following tadalafil use. It is postulated that this is due to alteration in the optic nerve head perfusion.

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Year:  2011        PMID： 21275598     DOI： 10.3109/08820538.2010.541320

Source DB:  PubMed          Journal:  Semin Ophthalmol        ISSN： 0882-0538            Impact factor:   1.975


  2 in total

Review 1.  Therapeutic Approaches to Treat Mitochondrial Diseases: "One-Size-Fits-All" and "Precision Medicine" Strategies.

Authors:  Emanuela Bottani; Costanza Lamperti; Alessandro Prigione; Valeria Tiranti; Nicola Persico; Dario Brunetti
Journal:  Pharmaceutics       Date:  2020-11-11       Impact factor: 6.321

2.  Sulthiame impairs mitochondrial function in vitro and may trigger onset of visual loss in Leber hereditary optic neuropathy.

Authors:  Marie-Christine Reinert; David Pacheu-Grau; Claudia B Catarino; Thomas Klopstock; Andreas Ohlenbusch; Michael Schittkowski; Ekkehard Wilichowski; Peter Rehling; Knut Brockmann
Journal:  Orphanet J Rare Dis       Date:  2021-02-04       Impact factor: 4.123
  2 in total

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