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Literature DB >> 21275391

A new trick (hydroxyl radical generation) for an old vitamin (B12).

Abstract

Photolysis of hydroxocobalamin in the presence of plasmid DNA (pBR322) results in DNA cleavage. Temporal control of hydroxyl radical production and DNA strand scission by hydroxocobalamin was demonstrated using a 2-deoxyribose assay and a plasmid relaxation assay, respectively. The light-driven hydroxocobalamin-mediated catalytic formation of hydroxyl radicals was demonstrated using radical scavenging studies of DNA cleavage and via recycling of a hydroxocobalamin-resin conjugate several times without loss of efficacy.

Entities: Chemical Disease Gene

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Year: 2011 PMID： 21275391 PMCID： PMC3077068 DOI： 10.1021/ja111585c

Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419

27 in total

1. Footprinting methods for analysis of pyrrole-imidazole polyamide/DNA complexes.

Authors: J W Trauger; P B Dervan
Journal: Methods Enzymol Date: 2001 Impact factor: 1.600

2. Hydroxyl radical mediated damage to proteins, with special reference to the crystallins.

Authors: P Guptasarma; D Balasubramanian; S Matsugo; I Saito
Journal: Biochemistry Date: 1992-05-05 Impact factor: 3.162

3. The deoxyribose assay: an assay both for 'free' hydroxyl radical and for site-specific hydroxyl radical production.

Authors: J M Gutteridge; B Halliwell
Journal: Biochem J Date: 1988-08-01 Impact factor: 3.857

4. A mechanism for the production of ethylene from methional. The generation of the hydroxyl radical by xanthine oxidase.

Authors: C Beauchamp; I Fridovich
Journal: J Biol Chem Date: 1970-09-25 Impact factor: 5.157

5. Dynamics of DNA condensation.

Authors: D Porschke
Journal: Biochemistry Date: 1984-10-09 Impact factor: 3.162

6. Ultrafine titanium dioxide particles in the absence of photoactivation can induce oxidative damage to human bronchial epithelial cells.

Authors: Jia-Ran Gurr; Alexander S S Wang; Chien-Hung Chen; Kun-Yan Jan
Journal: Toxicology Date: 2005-09-15 Impact factor: 4.221

5. The protective action of osmolytes on the deleterious effects of gamma rays and atmospheric pressure plasma on protein conformational changes.

Authors: Pankaj Attri; Minsup Kim; Thapanut Sarinont; Eun Ha Choi; Hyunwoong Seo; Art E Cho; Kazunori Koga; Masaharu Shiratani
Journal: Sci Rep Date: 2017-08-18 Impact factor: 4.379

5 in total

A new trick (hydroxyl radical generation) for an old vitamin (B12).

1. Footprinting methods for analysis of pyrrole-imidazole polyamide/DNA complexes.

2. Hydroxyl radical mediated damage to proteins, with special reference to the crystallins.

3. The deoxyribose assay: an assay both for 'free' hydroxyl radical and for site-specific hydroxyl radical production.

4. A mechanism for the production of ethylene from methional. The generation of the hydroxyl radical by xanthine oxidase.

5. Dynamics of DNA condensation.

6. Ultrafine titanium dioxide particles in the absence of photoactivation can induce oxidative damage to human bronchial epithelial cells.

7. Structural analysis of RNA in living cells by in vivo synchrotron X-ray footprinting.

8. Modification of alpha-chymotrypsin using a water-soluble photo-Fenton reagent.

9. Hydroxyl-radical-induced iron-catalysed degradation of 2-deoxyribose. Quantitative determination of malondialdehyde.

10. A photolabile ligand for light-activated release of caged copper.

1. Visible-to-NIR-Light Activated Release: From Small Molecules to Nanomaterials.

2. Visible Light-Induced Radical Mediated DNA Damage.

3. Fluorophore Assisted Photolysis of Thiolato-Cob(III)alamins.

4. TD-DFT insight into photodissociation of the Co-C bond in coenzyme B12.

5. The protective action of osmolytes on the deleterious effects of gamma rays and atmospheric pressure plasma on protein conformational changes.