Literature DB >> 21274606

Actinomycins like anti-cancer photo-sensitizers.

Nikolai Vekshin1.   

Abstract

Spectroscopic and microscopic study on application of actinomycins as anti-tumor photo-sensitizing drugs was carried out in this work. It has been shown that 7-aminoactinomycin (7AAMD) and actinomycin D (AMD) inside cells of line HeLa bind not only with DNA, but also with proteins. Fluorescence of 7AAMD in HeLa cells and destruction of these cells by photosensitizing with actinomycin D were detected. When photo-destruction occurs, the antibiotic is released out from destroyed cells. © Springer Science+Business Media, LLC 2011

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Year:  2011        PMID： 21274606     DOI： 10.1007/s10895-010-0825-8

Source DB:  PubMed          Journal:  J Fluoresc        ISSN： 1053-0509            Impact factor:   2.217


  10 in total

1.  Photodynamic action of actinomycin D: an EPR spin trapping study.

Authors:  J X Pan; Y Liu; S P Zhang; T C Tu; S D Yao; N Y Lin
Journal:  Biochim Biophys Acta       Date:  2001-07-02

2.  The nature of actinomycin D binding to d(AACCAXYG) sequence motifs.

Authors:  Fu-Ming Chen; Feng Sha; Ko-Hsin Chin; Shan-Ho Chou
Journal:  Nucleic Acids Res       Date:  2004-01-09       Impact factor: 16.971

3.  [A study of interaction of 7-aminoactinomycin D with DNA by fluorescence correlation spectroscopy].

Authors:  A E Kovalev; A A Iakovenko; N L Vekshin
Journal:  Biofizika       Date:  2004 Nov-Dec

4.  [Hairpin oligonucleotides as actinomycin carriers].

Authors:  N L Vekshin; I V Savintsev
Journal:  Biofizika       Date:  2009 Nov-Dec

5.  Anti-leukemia selectivity in actinomycin analogues.

Authors:  F Takusagawa; R G Carlson; R F Weaver
Journal:  Bioorg Med Chem       Date:  2001-03       Impact factor: 3.641

6.  Incorporation of triated actinomycin D into drug-sensitive and drug-resistant HeLa cells.

Authors:  M N Goldstein; K Hamm; E Amrod
Journal:  Science       Date:  1966-03-25       Impact factor: 47.728

7.  7-Amino-actinomycin D as a cytochemical probe. I. Spectral properties.

Authors:  J E Gill; M M Jotz; S G Young; E J Modest; S K Sengupta
Journal:  J Histochem Cytochem       Date:  1975-11       Impact factor: 2.479

8.  Prompt non-stacking binding of actinomycin D to hairpin oligonucleotide HP1 and slow redistribution from HP1 to DNA.

Authors:  Nikolai Vekshin; Alexander Kovalev
Journal:  J Biochem       Date:  2006-07-21       Impact factor: 3.387

9.  Effect of actinomycin D-containing lipid vesicles on murine renal adenocarcinoma.

Authors:  A Kedar; E Mayhew; R H Moore; P Williams; G P Murphy
Journal:  J Surg Oncol       Date:  1980       Impact factor: 3.454

10.  [Caffeine clusters as transmitters of actinomycin antibiotics to DNA in solutions].

Authors:  M A Bitekhtina; N L Vekshin
Journal:  Bioorg Khim       Date:  2008 Mar-Apr
  10 in total

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