Literature DB >> 2127424

Phase II evaluation of recombinant gamma-interferon in patients with advanced pancreatic carcinoma: a Southwest Oncology Group study.

D D Von Hoff1, T R Fleming, J S Macdonald, P J Goodman, J Van Damme, T D Brown, T O'Rourke, L G Feun, M D Keppen.   

Abstract

Thirty evaluable patients with advanced carcinoma of the pancreas received treatment with either daily x 5 bolus or continuous infusion x 5 days recombinant gamma-interferon. No responses were noted. Major toxicities included fever, hypotension, and flu-like symptoms. gamma-Interferon does not appear to be an active single agent for patients with advanced pancreatic cancer.

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Year:  1990        PMID: 2127424

Source DB:  PubMed          Journal:  J Biol Response Mod        ISSN: 0732-6580


  6 in total

Review 1.  IFN-γ: A cytokine at the right time, is in the right place.

Authors:  J Daniel Burke; Howard A Young
Journal:  Semin Immunol       Date:  2019-06-17       Impact factor: 11.130

2.  IFNγ induces JAK1/STAT1/p65 NFκB-dependent interleukin-8 expression in ovarian cancer cells, resulting in their increased migration.

Authors:  Sveta Padmanabhan; Bijaya Gaire; Yue Zou; Mohammad M Uddin; Daniel DeLeon; Ivana Vancurova
Journal:  Int J Biochem Cell Biol       Date:  2021-10-06       Impact factor: 5.085

Review 3.  Cytokine-based biotherapy of gastrointestinal tumors.

Authors:  J Buer; H Kirchner; A Schomburg; A Schüler; M Manns; E Lopez-Hänninen; S Duensing; H Poliwoda; J Atzpodien
Journal:  Clin Investig       Date:  1994-07

Review 4.  Interferon-Gamma at the Crossroads of Tumor Immune Surveillance or Evasion.

Authors:  Flávia Castro; Ana Patrícia Cardoso; Raquel Madeira Gonçalves; Karine Serre; Maria José Oliveira
Journal:  Front Immunol       Date:  2018-05-04       Impact factor: 7.561

Review 5.  Chemotherapy and radiotherapy for advanced pancreatic cancer.

Authors:  Venessa Chin; Adnan Nagrial; Katrin Sjoquist; Chelsie A O'Connor; Lorraine Chantrill; Andrew V Biankin; Rob Jpm Scholten; Desmond Yip
Journal:  Cochrane Database Syst Rev       Date:  2018-03-20

Review 6.  The Interactions Between Cancer Stem Cells and the Innate Interferon Signaling Pathway.

Authors:  Laura Martin-Hijano; Bruno Sainz
Journal:  Front Immunol       Date:  2020-03-31       Impact factor: 7.561

  6 in total

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