PURPOSE: Research indicates that patients with chronic temporal lobe epilepsy (TLE) exhibit cerebellar atrophy compared to healthy controls, but the degree to which specific regions of the cerebellum are affected remains unclear. The purpose of this study was to characterize the extent and lateralization of atrophy in individual cerebellar lobes and subregions in unilateral TLE using advanced quantitative magnetic resonance imaging (MRI) techniques. METHODS: Study participants were 46 persons with TLE and 31 age- and gender- matched healthy controls. All participants underwent high-resolution MRI with manual tracing of the cerebellum yielding gray and white matter volumes of the right and left anterior lobes, superior posterior lobes, inferior posterior lobes, and corpus medullare. The degree to which asymmetric versus generalized abnormalities was evident in unilateral chronic TLE was determined and related to selected clinical seizure features (age of onset, duration of disorder). KEY FINDINGS: There were no lateralized abnormalities in cerebellar gray matter or white matter in patients with right or left TLE (all p's > 0.2). Compared with controls, unilateral TLE was associated with significant bilateral reductions in the superior (p = 0.032) and inferior (p = 0.023) posterior lobes, whereas volume was significantly increased in the anterior lobes (p = 0.002), especially in patients with early onset TLE, and not significantly different in the corpus medullare (p = 0.71). Total superior cerebellar tissue volumes were reduced in association with increasing duration of epilepsy. SIGNIFICANCE: Patients with unilateral TLE exhibit a pattern of bilateral cerebellar pathology characterized by atrophy of the superior and inferior posterior lobes, hypertrophy of the anterior lobe, and no effect on the corpus medullare. Cross-sectional analyses show that specific aspects of cerebellar pathology are associated with neurodevelopmental (anterior lobe) or chronicity-related (superior posterior lobe) features of the disorder. Wiley Periodicals, Inc.
PURPOSE: Research indicates that patients with chronic temporal lobe epilepsy (TLE) exhibit cerebellar atrophy compared to healthy controls, but the degree to which specific regions of the cerebellum are affected remains unclear. The purpose of this study was to characterize the extent and lateralization of atrophy in individual cerebellar lobes and subregions in unilateral TLE using advanced quantitative magnetic resonance imaging (MRI) techniques. METHODS: Study participants were 46 persons with TLE and 31 age- and gender- matched healthy controls. All participants underwent high-resolution MRI with manual tracing of the cerebellum yielding gray and white matter volumes of the right and left anterior lobes, superior posterior lobes, inferior posterior lobes, and corpus medullare. The degree to which asymmetric versus generalized abnormalities was evident in unilateral chronic TLE was determined and related to selected clinical seizure features (age of onset, duration of disorder). KEY FINDINGS: There were no lateralized abnormalities in cerebellar gray matter or white matter in patients with right or left TLE (all p's > 0.2). Compared with controls, unilateral TLE was associated with significant bilateral reductions in the superior (p = 0.032) and inferior (p = 0.023) posterior lobes, whereas volume was significantly increased in the anterior lobes (p = 0.002), especially in patients with early onset TLE, and not significantly different in the corpus medullare (p = 0.71). Total superior cerebellar tissue volumes were reduced in association with increasing duration of epilepsy. SIGNIFICANCE: Patients with unilateral TLE exhibit a pattern of bilateral cerebellar pathology characterized by atrophy of the superior and inferior posterior lobes, hypertrophy of the anterior lobe, and no effect on the corpus medullare. Cross-sectional analyses show that specific aspects of cerebellar pathology are associated with neurodevelopmental (anterior lobe) or chronicity-related (superior posterior lobe) features of the disorder. Wiley Periodicals, Inc.
Authors: N C Andreasen; G Cohen; G Harris; T Cizadlo; J Parkkinen; K Rezai; V W Swayze Journal: J Neuropsychiatry Clin Neurosci Date: 1992 Impact factor: 2.198
Authors: Deepa Preeti Ramasamy; Ralph H B Benedict; Jennifer L Cox; David Fritz; Nadir Abdelrahman; Sara Hussein; Alireza Minagar; Michael G Dwyer; Robert Zivadinov Journal: J Neurol Sci Date: 2009-02-06 Impact factor: 3.181
Authors: Rebecca S N Liu; Louis Lemieux; Gail S Bell; Sanjay M Sisodiya; Philippa A Bartlett; Simon D Shorvon; Josemir W A S Sander; John S Duncan Journal: Epilepsia Date: 2005-09 Impact factor: 5.864
Authors: Michelle N Valadão; Erica R Coimbra; Michele C Landemberger; Tonicarlo R Velasco; Vera C Terra; Lauro Wichert-Ana; Veriano Alexandre; David Araújo; Ricardo Guarnieri; Vilma R Martins; Antônio Carlos Santos; Américo C Sakamoto; Roger Walz Journal: Neurol Sci Date: 2013-10-05 Impact factor: 3.307
Authors: Luke A Allen; Sjoerd B Vos; Rajesh Kumar; Jennifer A Ogren; Rebecca K Harper; Gavin P Winston; Simona Balestrini; Britta Wandschneider; Catherine A Scott; Sebsatien Ourselin; John S Duncan; Samden D Lhatoo; Ronald M Harper; Beate Diehl Journal: Epilepsia Date: 2019-03-14 Impact factor: 5.864
Authors: Ricardo Saute; Kevin Dabbs; Jana E Jones; Daren C Jackson; Michael Seidenberg; Bruce P Hermann Journal: PLoS One Date: 2014-04-23 Impact factor: 3.240
Authors: Bruce Hermann; Lisa L Conant; Cole J Cook; Gyujoon Hwang; Camille Garcia-Ramos; Kevin Dabbs; Veena A Nair; Jedidiah Mathis; Charlene N Rivera Bonet; Linda Allen; Dace N Almane; Karina Arkush; Rasmus Birn; Edgar A DeYoe; Elizabeth Felton; Rama Maganti; Andrew Nencka; Manoj Raghavan; Umang Shah; Veronica N Sosa; Aaron F Struck; Candida Ustine; Anny Reyes; Erik Kaestner; Carrie McDonald; Vivek Prabhakaran; Jeffrey R Binder; Mary E Meyerand Journal: Neuroimage Clin Date: 2020-07-10 Impact factor: 4.881
Authors: Manar Ibdali; Marios Hadjivassiliou; Richard A Grünewald; Priya D Shanmugarajah Journal: Int J Environ Res Public Health Date: 2021-01-08 Impact factor: 3.390
Authors: Rodney Ogwang; Albert Ningwa; Pamela Akun; Paul Bangirana; Ronald Anguzu; Rajarshi Mazumder; Noriko Salamon; Oliver Johannes Henning; Charles R Newton; Catherine Abbo; Amos Deogratius Mwaka; Kevin Marsh; Richard Idro Journal: Front Neurol Date: 2021-06-03 Impact factor: 4.003
Authors: Johannes T Reiter; Bastian David; Selma Enders; Conrad C Prillwitz; Tobias Bauer; Deniz Atalay; Anna Tietze; Angela M Kaindl; Vera Keil; Alexander Radbruch; Bernd Weber; Albert J Becker; Christian E Elger; Rainer Surges; Theodor Rüber Journal: Neurol Neuroimmunol Neuroinflamm Date: 2021-08-13