Literature DB >> 21269253

Evaluation of effect of triterpenes and limonoids on cell growth, cell cycle and apoptosis in human tumor cell line.

Cristiane M Cazal1, Kantima Choosang, Vanessa Gisele P Severino, Marcio S Soares, Andre Lucio F Sarria, Joao B Fernandes, Maria Fatima G F Silva, Paulo Cezar Vieira, Pannee Pakkong, Gabriela M Almeida, M Helena Vasconcelos, Maria S J Nascimento, Madalena M M Pinto.   

Abstract

Six triterpenes and eight limonoids were evaluated for their capacity to inhibit the growth of three human tumour cell lines, breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and melanoma (A375-C5). The mechanisms involved in the observed cell growth arrest of the four most potent compounds were carried out by studying their effect in cell cycle profile and programmed cell death. The results showed that one triterpene (odoratol) and two limonoids (gedunin and cedrelone) caused cell cycle arrest while only the limonoids gedunin and cedrelone were found to be very potent inducers of apoptosis.

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Year:  2010        PMID： 21269253     DOI： 10.2174/187152010794728620

Source DB:  PubMed          Journal:  Anticancer Agents Med Chem        ISSN： 1871-5206            Impact factor:   2.505


  7 in total

1.  Thermodynamic Analysis of the Geldanamycin-Hsp90 Interaction in a Whole Cell Lysate Using a Mass Spectrometry-Based Proteomics Approach.

Authors:  Yingrong Xu; M Ariel Geer Wallace; Michael C Fitzgerald
Journal:  J Am Soc Mass Spectrom       Date:  2016-08-16       Impact factor: 3.109

2.  Using the heat-shock response to discover anticancer compounds that target protein homeostasis.

Authors:  Sandro Santagata; Ya-Ming Xu; E M Kithsiri Wijeratne; Renee Kontnik; Christine Rooney; Casey C Perley; Hyoungtae Kwon; Jon Clardy; Santosh Kesari; Luke Whitesell; Susan Lindquist; A A Leslie Gunatilaka
Journal:  ACS Chem Biol       Date:  2011-11-30       Impact factor: 5.100

3.  Identification of the sAPRIL binding peptide and its growth inhibition effects in the colorectal cancer cells.

Authors:  Xiao-qing He; Jing Guan; Fang Liu; Jing Li; Mei-rong He
Journal:  PLoS One       Date:  2015-03-31       Impact factor: 3.240

4.  Antioxidant Activity and Genotoxic Assessment of Crabwood (Andiroba, Carapa guianensis Aublet) Seed Oils.

Authors:  Carlos F Araujo-Lima; Andreia S Fernandes; Erika M Gomes; Larisse L Oliveira; Andrea F Macedo; Rosemar Antoniassi; Allan E Wilhelm; Claudia A F Aiub; Israel Felzenszwalb
Journal:  Oxid Med Cell Longev       Date:  2018-05-02       Impact factor: 6.543

5.  Effect of Post-Harvest LED and UV Light Irradiation on the Accumulation of Flavonoids and Limonoids in the Segments of Newhall Navel Oranges (Citrus sinensis Osbeck).

Authors:  Shengyu Liu; Linping Hu; Dong Jiang; Wanpeng Xi
Journal:  Molecules       Date:  2019-05-06       Impact factor: 4.411

6.  Novel compound cedrelone inhibits hepatocellular carcinoma progression via PBLD and Ras/Rap1.

Authors:  Jiansong Wu; Qiang Niu; Jie Yuan; Xiaodan Xu; Liuxia Cao
Journal:  Exp Ther Med       Date:  2019-10-07       Impact factor: 2.447

Review 7.  Chemical Compounds and Biologic Activities: A Review of Cedrela Genus.

Authors:  Thalya Soares R Nogueira; Michel de S Passos; Lara Pessanha S Nascimento; Mayara Barreto de S Arantes; Noemi O Monteiro; Samyra Imad da S Boeno; Almir de Carvalho Junior; Otoniel de A Azevedo; Wagner da S Terra; Milena Gonçalves C Vieira; Raimundo Braz-Filho; Ivo J Curcino Vieira
Journal:  Molecules       Date:  2020-11-18       Impact factor: 4.411
  7 in total

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