Literature DB >> 21269061

Interaction of ACE and CYP11B2 genes on blood pressure response to hydrochlorothiazide in Han Chinese hypertensive patients.

Yun Li1, Yong Zhou, Peng Yang, Jian Qing Niu, Ying Wu, Dan Dan Zhao, Shou Ling Wu.   

Abstract

To valuate whether angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and aldosterone synthase (CYP11B2) gene -344T/C polymorphism are associated with individual response to hydrochlorothiazide (HCTZ) in the Han Chinese population with essential hypertension. We enrolled 829 mild/moderate hypertensive patients and 12.5 mg of HCTZ was given daily. After 6 weeks, the results showed that the ACE I/D polymorphism, not the CYP11B2 -344T/C polymorphism, was associated with systolic blood pressure (SBP) response to HCTZ (P = 0.009) in the Han Chinese population with essential hypertension, with no interaction.

Entities:  

Mesh：

Substances：

Year:  2011        PMID： 21269061     DOI： 10.3109/10641963.2010.531838

Source DB:  PubMed          Journal:  Clin Exp Hypertens        ISSN： 1064-1963            Impact factor:   1.749


  6 in total

1.  Associations between human aldosterone synthase CYP11B2 (-344T/C) gene polymorphism and antihypertensive response to valsartan in Chinese patients with essential hypertension.

Authors:  Xu Ji; Hua Qi; Dong-Bao Li; Rong-Kun Liu; Yang Zheng; Hai-Ling Chen; Jin-Cheng Guo
Journal:  Int J Clin Exp Med       Date:  2015-01-15

Review 2.  Genomics and Pharmacogenomics of Salt-sensitive Hypertension.

Authors:  Ines Armando; Van Anthony M Villar; Pedro A Jose
Journal:  Curr Hypertens Rev       Date:  2015

Review 3.  Genome-Wide and Gene-Based Meta-Analyses Identify Novel Loci Influencing Blood Pressure Response to Hydrochlorothiazide.

Authors:  Erika Salvi; Zhiying Wang; Federica Rizzi; Yan Gong; Caitrin W McDonough; Sandosh Padmanabhan; Timo P Hiltunen; Chiara Lanzani; Roberta Zaninello; Martina Chittani; Kent R Bailey; Antti-Pekka Sarin; Matteo Barcella; Olle Melander; Arlene B Chapman; Paolo Manunta; Kimmo K Kontula; Nicola Glorioso; Daniele Cusi; Anna F Dominiczak; Julie A Johnson; Cristina Barlassina; Eric Boerwinkle; Rhonda M Cooper-DeHoff; Stephen T Turner
Journal:  Hypertension       Date:  2016-10-31       Impact factor: 10.190

4.  Genomics and pharmacogenomics of salt-sensitive hypertension Minireview.

Authors:  Ines Armando; Van Anthony M Villar; Pedro A Jose
Journal:  Curr Hypertens Rev       Date:  2015

5.  Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker.

Authors:  Stephen T Turner; Kent R Bailey; Gary L Schwartz; Arlene B Chapman; High Seng Chai; Eric Boerwinkle
Journal:  Hypertension       Date:  2012-05-07       Impact factor: 10.190

6.  Pharmacogenomics study of thiazide diuretics and QT interval in multi-ethnic populations: the cohorts for heart and aging research in genomic epidemiology.

Authors:  A A Seyerle; C M Sitlani; R Noordam; S M Gogarten; J Li; X Li; D S Evans; F Sun; M A Laaksonen; A Isaacs; K Kristiansson; H M Highland; J D Stewart; T B Harris; S Trompet; J C Bis; G M Peloso; J A Brody; L Broer; E L Busch; Q Duan; A M Stilp; C J O'Donnell; P W Macfarlane; J S Floyd; J A Kors; H J Lin; R Li-Gao; T Sofer; R Méndez-Giráldez; S R Cummings; S R Heckbert; A Hofman; I Ford; Y Li; L J Launer; K Porthan; C Newton-Cheh; M D Napier; K F Kerr; A P Reiner; K M Rice; J Roach; B M Buckley; E Z Soliman; R de Mutsert; N Sotoodehnia; A G Uitterlinden; K E North; C R Lee; V Gudnason; T Stürmer; F R Rosendaal; K D Taylor; K L Wiggins; J G Wilson; Y-Di Chen; R C Kaplan; K Wilhelmsen; L A Cupples; V Salomaa; C van Duijn; J W Jukema; Y Liu; D O Mook-Kanamori; L A Lange; R S Vasan; A V Smith; B H Stricker; C C Laurie; J I Rotter; E A Whitsel; B M Psaty; C L Avery
Journal:  Pharmacogenomics J       Date:  2017-07-18       Impact factor: 3.550
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.