| Literature DB >> 21268631 |
Lei Cui1, Ye Zhong, Weiping Zhu, Yufang Xu, Qingshan Du, Xin Wang, Xuhong Qian, Yi Xiao.
Abstract
Based on the hypoxia prodrug moiety of p-nitrobenzyl, a selective ratiometric fluorescent sensor (RHP) for the detection of microenvironment hypoxia was designed and synthesized. RHP can be selectively activated by bioreductive enzymes (NTR) and results in an evident blue to green fluorescent emission wavelength change in both solution phases and in cell lines, which might be the first fluorescent ratiometric probe for hypoxia in solid tumors.Entities:
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Year: 2011 PMID： 21268631 DOI： 10.1021/ol102975t
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005