Literature DB >> 21268057

New insights into the inactivation of gastric tumor suppressor RUNX3: the role of H. pylori infection.

Ying-Hung Nicole Tsang1, Acacia Lamb, Lin-Feng Chen.   

Abstract

Runt-related transcription factor 3, or RUNX3, is a tumor suppressor in gastric cancer. Inactivation of RUNX3 is causally associated with the genesis of gastric cancer, since RUNX3 is frequently inactivated in gastric cancers by hemizygous deletion, hypermethylation of its promoter, or protein mislocalization. Infection with Helicobacter pylori is the strongest risk factor for the development of gastric cancer. Recent studies have indicated that H. pylori infection plays an important role in the inactivation of RUNX3, and that this inactivation contributes to the pathogenesis of H. pylori. Here we summarize these recent advances and discuss their significances in understanding the initiation and development of gastric cancer.
Copyright © 2010 Wiley-Liss, Inc.

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Year:  2011        PMID： 21268057      PMCID： PMC3909029          DOI： 10.1002/jcb.22964

Source DB:  PubMed          Journal:  J Cell Biochem        ISSN： 0730-2312            Impact factor:   4.429


  50 in total

Review 1.  Phosphorylation, acetylation and ubiquitination: the molecular basis of RUNX regulation.

Authors:  Suk-Chul Bae; Yong Hee Lee
Journal:  Gene       Date:  2005-12-01       Impact factor: 3.688

Review 2.  Pathology and molecular biology of gastric cancer.

Authors:  Matti Vauhkonen; Hanna Vauhkonen; Pentti Sipponen
Journal:  Best Pract Res Clin Gastroenterol       Date:  2006       Impact factor: 3.043

3.  RUNX3 inhibits the expression of vascular endothelial growth factor and reduces the angiogenesis, growth, and metastasis of human gastric cancer.

Authors:  Zhihai Peng; Daoyan Wei; Liwei Wang; Huamei Tang; Jun Zhang; Xiangdong Le; Zhiliang Jia; Qiang Li; Keping Xie
Journal:  Clin Cancer Res       Date:  2006-11-01       Impact factor: 12.531

4.  Inflammatory processes triggered by Helicobacter pylori infection cause aberrant DNA methylation in gastric epithelial cells.

Authors:  Tohru Niwa; Tetsuya Tsukamoto; Takeshi Toyoda; Akiko Mori; Harunari Tanaka; Takao Maekita; Masao Ichinose; Masae Tatematsu; Toshikazu Ushijima
Journal:  Cancer Res       Date:  2010-02-02       Impact factor: 12.701

Review 5.  Helicobacter pylori eradication to prevent gastric cancer: underlying molecular and cellular mechanisms.

Authors:  Shingo Tsuji; Masahiko Tsujii; Hiroaki Murata; Tsutomu Nishida; Masato Komori; Masakazu Yasumaru; Shuji Ishii; Yoshiaki Sasayama; Sunao Kawano; Norio Hayashi
Journal:  World J Gastroenterol       Date:  2006-03-21       Impact factor: 5.742

6.  Decreased expression of RUNX3 is correlated with tumor progression and poor prognosis in patients with esophageal squamous cell carcinoma.

Authors:  Hironori Sugiura; Hideyuki Ishiguro; Yoshiyuki Kuwabara; Masahiro Kimura; Akira Mitsui; Yoichiro Mori; Ryo Ogawa; Takeyasu Katada; Koshiro Harata; Yoshitaka Fujii
Journal:  Oncol Rep       Date:  2008-03       Impact factor: 3.906

7.  Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation.

Authors:  Yun-Hye Jin; Eun-Joo Jeon; Qing-Lin Li; Yong Hee Lee; Joong-Kook Choi; Wun-Jae Kim; Kwang-Youl Lee; Suk-Chul Bae
Journal:  J Biol Chem       Date:  2004-05-10       Impact factor: 5.157

8.  Methylation of RUNX3 in various types of human cancers and premalignant stages of gastric carcinoma.

Authors:  Tai Young Kim; Hyeon Joo Lee; Kyu Sang Hwang; Minjin Lee; Jae Won Kim; Yung-Jue Bang; Gyeong Hoon Kang
Journal:  Lab Invest       Date:  2004-04       Impact factor: 5.662

Review 9.  Runx3 controls growth and differentiation of gastric epithelial cells in mammals.

Authors:  Hiroshi Fukamachi
Journal:  Dev Growth Differ       Date:  2006-01       Impact factor: 2.053

10.  Runt-related transcription factor RUNX3 is a target of MDM2-mediated ubiquitination.

Authors:  Xin-Zi Chi; Jiyeon Kim; Yong-Hee Lee; Jung-Won Lee; Kyeong-Sook Lee; Heejun Wee; Wun-Jae Kim; Woo-Yoon Park; Byung-Chul Oh; Gary S Stein; Yoshiaki Ito; Andre J van Wijnen; Suk-Chul Bae
Journal:  Cancer Res       Date:  2009-10-06       Impact factor: 12.701
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  6 in total

Review 1.  Role of the Helicobacter pylori-induced inflammatory response in the development of gastric cancer.

Authors:  Acacia Lamb; Lin-Feng Chen
Journal:  J Cell Biochem       Date:  2013-03       Impact factor: 4.429

2.  Helicobacter, Inflammation, and Gastric Cancer.

Authors:  Antonia R Sepulveda
Journal:  Curr Pathobiol Rep       Date:  2013-03

3.  A Systematic In-silico Analysis of Helicobacter pylori Pathogenic Islands for Identification of Novel Drug Target Candidates.

Authors:  Deepthi Nammi; Nagendra S Yarla; Vladimir N Chubarev; Vadim V Tarasov; George E Barreto; Amita Martin Corolina Pasupulati; Gjumrakch Aliev; Nageswara Rao Reddy Neelapu
Journal:  Curr Genomics       Date:  2017-10       Impact factor: 2.236

4.  A 5-Gene Prognostic Combination for Predicting Survival of Patients with Gastric Cancer.

Authors:  Liang Song; Xiao-Yan Wang; Xiao-Feng He
Journal:  Med Sci Monit       Date:  2019-08-18

5.  Integrated Analysis Identifies an Immune-Based Prognostic Signature for the Mesenchymal Identity in Gastric Cancer.

Authors:  Dongzhu Peng; Bin Gu; Liming Ruan; Xingguo Zhang; Peng Shu
Journal:  Biomed Res Int       Date:  2020-04-09       Impact factor: 3.411

Review 6.  RUNX family: Oncogenes or tumor suppressors (Review).

Authors:  Beatriz Andrea Otálora-Otálora; Berta Henríquez; Liliana López-Kleine; Adriana Rojas
Journal:  Oncol Rep       Date:  2019-05-06       Impact factor: 3.906
  6 in total

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