Literature DB >> 2126690

Cell wall and membrane changes associated with ethambutol resistance in Mycobacterium tuberculosis H37Ra.

M Sareen1, G K Khuller.   

Abstract

Biochemical variations accompanying the acquisition of ethambutol (EMB) resistance in a single-step mutant of Mycobacterium tuberculosis H37Ra were analyzed. Comparative analysis of phospholipids revealed a reduced content in the EMB-resistant strain, particularly in the cell membrane fraction. Significant alterations were observed in the individual phospholipid content and phospholipid fatty acyl group composition of whole cells and subcellular fractions. Quantitative changes were seen in the chemical constituents of the cell walls of resistant cultures in comparison with those of EMB-susceptible cultures of M. tuberculosis. Alterations in the binding of 1-anilinonaphthalene-8-sulfonate to whole cells of an EMB-resistant strain indicated structural changes on the cell surface. Structural changes in the cell wall may play an important role in the resistance of M. tuberculosis H37Ra to EMB.

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Year:  1990        PMID： 2126690      PMCID： PMC171922          DOI： 10.1128/AAC.34.9.1773

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  19 in total

1.  Phosphorus assay in column chromatography.

Authors:  G R BARTLETT
Journal:  J Biol Chem       Date:  1959-03       Impact factor: 5.157

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Authors:  K TAKEYA; K HISATSUNE; Y INOUE
Journal:  J Bacteriol       Date:  1963-01       Impact factor: 3.490

3.  Mycobacterial cell walls. I. Methods of preparation and treatment with various chemicals.

Authors:  K TAKEYA; K HISATSUNE
Journal:  J Bacteriol       Date:  1963-01       Impact factor: 3.490

4.  A simple method for the isolation and purification of total lipides from animal tissues.

Authors:  J FOLCH; M LEES; G H SLOANE STANLEY
Journal:  J Biol Chem       Date:  1957-05       Impact factor: 5.157

5.  Inhibition of synthesis of arabinogalactan by ethambutol in Mycobacterium smegmatis.

Authors:  K Takayama; J O Kilburn
Journal:  Antimicrob Agents Chemother       Date:  1989-09       Impact factor: 5.191

6.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

Review 7.  Leprosy and the leprosy bacillus: recent developments in characterization of antigens and immunology of the disease.

Authors:  H Gaylord; P J Brennan
Journal:  Annu Rev Microbiol       Date:  1987       Impact factor: 15.500

8.  Effects of ethambutol on phospholipid metabolism in Mycobacterium smegmatis.

Authors:  J O Kilburn; K Takayama; E L Armstrong; J Greenberg
Journal:  Antimicrob Agents Chemother       Date:  1981-02       Impact factor: 5.191

9.  Drug-resistant tuberculosis in a southern California hospital. Trends from 1969 to 1984.

Authors:  I Ben-Dov; G R Mason
Journal:  Am Rev Respir Dis       Date:  1987-06

10.  Early changes in bacterial envelopes after inhibition of peptidoglycan synthesis, as shown by the use of a fluorescent probe.

Authors:  H J Rogers; G Wright
Journal:  J Gen Microbiol       Date:  1987-09
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5.  Mutations Found in embCAB, embR, and ubiA Genes of Ethambutol-Sensitive and -Resistant Mycobacterium tuberculosis Clinical Isolates from China.

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