BACKGROUND: We analyzed in the present study the influence of intracoronary autologous freshly isolated bone marrow cells transplantation (BMCs-Tx) on cardiac function in patients with acute myocardial infarction (AMI). METHODS AND RESULTS: The 32 patients with AMI were enrolled in this prospective nonrandomized study to either freshly isolated BMC-Tx or to a control group without cell therapy. Global left ventricular ejection fraction (LVEF) and the size of infarct area were determined by left ventriculography. We observed in patients with autologous freshly isolated BMCs-Tx at 6 months follow up a significant reduction of infarct size as compared to control group. Moreover, we found a significant increase of LVEF as well as infarct wall movement velocity at 6 months follow up in cell therapy group as compared to control group. In the control group there was no significant difference of LVEF, infarct size and infarct wall movement velocity between baseline and 6 months after AMI. CONCLUSIONS: These results demonstrate for the first time that intracoronary transplantation of autologous freshly isolated BMCs by use of a point of care system is safe, and may lead to improvement of cardiac function in patients with AMI.
BACKGROUND: We analyzed in the present study the influence of intracoronary autologous freshly isolated bone marrow cells transplantation (BMCs-Tx) on cardiac function in patients with acute myocardial infarction (AMI). METHODS AND RESULTS: The 32 patients with AMI were enrolled in this prospective nonrandomized study to either freshly isolated BMC-Tx or to a control group without cell therapy. Global left ventricular ejection fraction (LVEF) and the size of infarct area were determined by left ventriculography. We observed in patients with autologous freshly isolated BMCs-Tx at 6 months follow up a significant reduction of infarct size as compared to control group. Moreover, we found a significant increase of LVEF as well as infarct wall movement velocity at 6 months follow up in cell therapy group as compared to control group. In the control group there was no significant difference of LVEF, infarct size and infarct wall movement velocity between baseline and 6 months after AMI. CONCLUSIONS: These results demonstrate for the first time that intracoronary transplantation of autologous freshly isolated BMCs by use of a point of care system is safe, and may lead to improvement of cardiac function in patients with AMI.
Authors: Vinodh Jeevanantham; Matthew Butler; Andre Saad; Ahmed Abdel-Latif; Ewa K Zuba-Surma; Buddhadeb Dawn Journal: Circulation Date: 2012-06-22 Impact factor: 29.690
Authors: Ilkay Bozdag-Turan; R Goekmen Turan; Sophie Ludovicy; Ibrahim Akin; Stephan Kische; Henrik Schneider; Tim C Rehders; C Hakan Turan; Nicole S Arsoy; Tina Hermann; Liliya Paranskaya; Jasmin Ortak; Peter Kohlschein; Manuela Bastian; Kurtulus Sahin; Christoph A Nienaber; Hueseyin Ince Journal: BMC Res Notes Date: 2012-04-25
Authors: Ilkay Bozdag-Turan; R Goekmen Turan; C Hakan Turan; Sophie Ludovicy; Ibrahim Akin; Stephan Kische; Nicole S Arsoy; Henrik Schneider; Jasmin Ortak; Tim Rehders; Tina Hermann; Liliya Paranskaya; Peter Kohlschein; Manuela Bastian; A Tulga Ulus; Kurtulus Sahin; Hueseyin Ince; Christoph A Nienaber Journal: Cardiovasc Diabetol Date: 2011-11-25 Impact factor: 9.951
Authors: R G Turan; I Bozdag-T; C H Turan; J Ortak; I Akin; S Kische; H Schneider; M Rauchhaus; T C Rehders; T Kleinfeldt; C Belu; S Amen; T Hermann; S Yokus; M Brehm; S Steiner; T Chatterjee; K Sahin; C A Nienaber; H Ince Journal: J Cell Mol Med Date: 2012-04 Impact factor: 5.310