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Literature DB >> 21266177

Control of RNA processing by a large non-coding RNA over-expressed in carcinomas.

Rui Lin¹, Manami Roychowdhury-Saha, Chris Black, Andrew T Watt, Eric G Marcusson, Susan M Freier, Thomas S Edgington.

Abstract

RNA processing is vital for the high fidelity and diversity of eukaryotic transcriptomes and the encoded proteomes. However, control of RNA processing is not fully established. Σ RNA is a class of conserved large non-coding RNAs (murine Hepcarcin; human MALAT-1) up-regulated in carcinomas. Using antisense technology, we identified that RNA post-transcriptional modification is the most significant global function of Σ RNA. Specifically, processing of the pre-mRNAs of genes including Tissue Factor and Endoglin was altered by hydrolysis of Σ RNA/MALAT-1. These results support the hypothesis that Σ RNA/MALAT-1 is a regulatory molecule exerting roles in RNA post-transcriptional modification.

Entities: CellLine Chemical Disease Gene Species

Mesh：

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Year: 2011 PMID： 21266177 PMCID： PMC3065235 DOI： 10.1016/j.febslet.2011.01.030

Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124

21 in total

1. Construction of a 350-kb sequence-ready 11q13 cosmid contig encompassing the markers D11S4933 and D11S546: mapping of 11 genes and 3 tumor-associated translocation breakpoints.

Authors: M van Asseldonk; M Schepens; D de Bruijn; B Janssen; G Merkx; A Geurts van Kessel
Journal: Genomics Date: 2000-05-15 Impact factor: 5.736

Review 2. Mechanisms of alternative pre-messenger RNA splicing.

Authors: Douglas L Black
Journal: Annu Rev Biochem Date: 2003-02-27 Impact factor: 23.643

3. MALAT-1 enhances cell motility of lung adenocarcinoma cells by influencing the expression of motility-related genes.

Authors: Keiko Tano; Rie Mizuno; Tomoko Okada; Randeep Rakwal; Junko Shibato; Yoshinori Masuo; Kenichi Ijiri; Nobuyoshi Akimitsu
Journal: FEBS Lett Date: 2010-10-13 Impact factor: 4.124

Review 4. SRprises along a messenger's journey.

Authors: Yingqun Huang; Joan A Steitz
Journal: Mol Cell Date: 2005-03-04 Impact factor: 17.970

5. Complete sequence of the human tissue factor gene, a highly regulated cellular receptor that initiates the coagulation protease cascade.

Authors: N Mackman; J H Morrissey; B Fowler; T S Edgington
Journal: Biochemistry Date: 1989-02-21 Impact factor: 3.162

Review 6. Alternatively spliced tissue factor: a previously unknown piece in the puzzle of hemostasis.

Authors: Björn Szotowski; Silvio Antoniak; Ursula Rauch
Journal: Trends Cardiovasc Med Date: 2006-07 Impact factor: 6.677

7. Regulation of tissue factor gene expression in the monocyte procoagulant response to endotoxin.

Authors: S A Gregory; J H Morrissey; T S Edgington
Journal: Mol Cell Biol Date: 1989-06 Impact factor: 4.272

Review 8. Aberrant and alternative splicing in cancer.

Authors: Julian P Venables
Journal: Cancer Res Date: 2004-11-01 Impact factor: 12.701

9. 2'-O-(2-Methoxy)ethyl-modified anti-intercellular adhesion molecule 1 (ICAM-1) oligonucleotides selectively increase the ICAM-1 mRNA level and inhibit formation of the ICAM-1 translation initiation complex in human umbilical vein endothelial cells.

Authors: B F Baker; S S Lot; T P Condon; S Cheng-Flournoy; E A Lesnik; H M Sasmor; C F Bennett
Journal: J Biol Chem Date: 1997-05-02 Impact factor: 5.157

Review 10. Functional insights into the role of nuclear-retained long noncoding RNAs in gene expression control in mammalian cells.

Authors: Deepak K Singh; Kannanganattu V Prasanth
Journal: Chromosome Res Date: 2013-12 Impact factor: 5.239

Control of RNA processing by a large non-coding RNA over-expressed in carcinomas.

1. Construction of a 350-kb sequence-ready 11q13 cosmid contig encompassing the markers D11S4933 and D11S546: mapping of 11 genes and 3 tumor-associated translocation breakpoints.

Review 2. Mechanisms of alternative pre-messenger RNA splicing.

3. MALAT-1 enhances cell motility of lung adenocarcinoma cells by influencing the expression of motility-related genes.

Review 4. SRprises along a messenger's journey.

5. Complete sequence of the human tissue factor gene, a highly regulated cellular receptor that initiates the coagulation protease cascade.

Review 6. Alternatively spliced tissue factor: a previously unknown piece in the puzzle of hemostasis.

7. Regulation of tissue factor gene expression in the monocyte procoagulant response to endotoxin.

Review 8. Aberrant and alternative splicing in cancer.

9. 2'-O-(2-Methoxy)ethyl-modified anti-intercellular adhesion molecule 1 (ICAM-1) oligonucleotides selectively increase the ICAM-1 mRNA level and inhibit formation of the ICAM-1 translation initiation complex in human umbilical vein endothelial cells.

Review 10. Emerging role of endoglin (CD105) as a marker of angiogenesis with clinical potential in human malignancies.

1. Hidden treasures in unspliced EST data.

2. Malat1 is not an essential component of nuclear speckles in mice.

Review 3. Regulation of mammary epithelial cell homeostasis by lncRNAs.

4. Direct screening of plasma circulating microRNAs.

Review 5. Long noncoding RNAs: past, present, and future.

6. Cisplatin and paclitaxel target significant long noncoding RNAs in laryngeal squamous cell carcinoma.

7. RNA splicing control: yet another gene regulatory role for long nuclear noncoding RNAs.

Review 8. The bright side of dark matter: lncRNAs in cancer.

Review 9. MALAT1 -- a paradigm for long noncoding RNA function in cancer.

Review 10. Functional insights into the role of nuclear-retained long noncoding RNAs in gene expression control in mammalian cells.