Literature DB >> 2126464

Antithrombin III: structural and functional aspects.

L Mourey1, J P Samama, M Delarue, J Choay, J C Lormeau, M Petitou, D Moras.   

Abstract

Antithrombin III is a plasma glycoprotein responsible for thrombin inhibition in the blood coagulation cascade. The X-ray structure of its cleaved form has been determined and refined to 3.2 A resolution. The overall topology is similar to that of alpha 1-antitrypsin, another member of the serpin (serine protease inhibitor) superfamily. The biological activity of antithrombin III is mediated by a polysaccharide, heparin. The binding site of this effector is described. A possible structural transition from the native to the cleaved structure is discussed.

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Year:  1990        PMID： 2126464     DOI： 10.1016/0300-9084(90)90123-x

Source DB:  PubMed          Journal:  Biochimie        ISSN： 0300-9084            Impact factor:   4.079


  6 in total

1.  Production of recombinant h-AT III with mammalian cell cultures using capillary electrophoresis for product monitoring.

Authors:  R Freitag; O W Reif; R Weidemann; G Kretzmer
Journal:  Cytotechnology       Date:  1996-01       Impact factor: 2.058

2.  Probing serpin reactive-loop conformations by proteolytic cleavage.

Authors:  W S Chang; M R Wardell; D A Lomas; R W Carrell
Journal:  Biochem J       Date:  1996-03-01       Impact factor: 3.857

3.  Convergent evolution of the genomes of marine mammals.

Authors:  Andrew D Foote; Yue Liu; Gregg W C Thomas; Tomáš Vinař; Jessica Alföldi; Jixin Deng; Shannon Dugan; Cornelis E van Elk; Margaret E Hunter; Vandita Joshi; Ziad Khan; Christie Kovar; Sandra L Lee; Kerstin Lindblad-Toh; Annalaura Mancia; Rasmus Nielsen; Xiang Qin; Jiaxin Qu; Brian J Raney; Nagarjun Vijay; Jochen B W Wolf; Matthew W Hahn; Donna M Muzny; Kim C Worley; M Thomas P Gilbert; Richard A Gibbs
Journal:  Nat Genet       Date:  2015-01-26       Impact factor: 38.330

Review 4.  Glycosaminoglycans and the regulation of blood coagulation.

Authors:  M C Bourin; U Lindahl
Journal:  Biochem J       Date:  1993-01-15       Impact factor: 3.857

5.  Elevated circulating levels of tissue factor-positive microvesicles are associated with distant metastasis in lung cancer.

Authors:  Jo-Chi Tseng; Liang-Che Chang; Boy-Yiing Jiang; Yu-Chih Liu; Hung-Jie Chen; Chih-Teng Yu; Chung-Ching Hua
Journal:  J Cancer Res Clin Oncol       Date:  2013-10-30       Impact factor: 4.553

6.  Heparin binding domain peptides of antithrombin III: analysis by isothermal titration calorimetry and circular dichroism spectroscopy.

Authors:  R Tyler-Cross; M Sobel; D Marques; R B Harris
Journal:  Protein Sci       Date:  1994-04       Impact factor: 6.725
  6 in total

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