Yosef Mohamed-Azzam Zakout1, Yousra Altegani Ezeldeen. 1. Department of Histopathology and Cytology, Faculty of Medical Laboratory Sciences, University of Khartoum, P.O. Box 11081, Khartoum, 11111, Sudan. yosifzakot@yahoo.com
Abstract
PURPOSE: This study aimed to assess the qualitative changes in the amount of acid mucin in colorectal carcinoma (CRC) compared to normal colon. METHODS: A total number of 100 samples were examined, 50 were colorectal cancer samples (cases) and 50 were normal (controls), all were stained with Alcian blue method. RESULTS: Acid mucin increased, in different levels, in 30 (60%) of the cases compared to only six (12%) of controls (P < 0.0001). However, complete absence of acid mucin was detected among 10 (20%) of cases compared to none among controls. CONCLUSIONS: CRC is associated with secretion of increased amounts of acid mucin in most cases, and that should be considered as a valuable histological finding.
PURPOSE: This study aimed to assess the qualitative changes in the amount of acid mucin in colorectal carcinoma (CRC) compared to normal colon. METHODS: A total number of 100 samples were examined, 50 were colorectal cancer samples (cases) and 50 were normal (controls), all were stained with Alcian blue method. RESULTS: Acid mucin increased, in different levels, in 30 (60%) of the cases compared to only six (12%) of controls (P < 0.0001). However, complete absence of acid mucin was detected among 10 (20%) of cases compared to none among controls. CONCLUSIONS: CRC is associated with secretion of increased amounts of acid mucin in most cases, and that should be considered as a valuable histological finding.
Authors: Aldona Kasprzak; Agnieszka Seraszek-Jaros; Joanna Jagielska; Celina Helak-Łapaj; Elżbieta Siodła; Jacek Szmeja; Elżbieta Kaczmarek Journal: Int J Mol Sci Date: 2019-09-16 Impact factor: 5.923