Literature DB >> 21264398

Hyaluronan metabolism in remodeling extracellular matrix: probes for imaging and therapy of breast cancer.

M Veiseh1, E A Turley.   

Abstract

Clinical and experimental evidence increasingly support the concept of cancer as a disease that emulates a component of wound healing, in particular abnormal stromal extracellular matrix remodeling. Here we review the biology and function of one remodeling process, hyaluronan (HA) metabolism, which is essential for wound resolution but closely linked to breast cancer (BCA) progression. Components of the HA metabolic cycle (HAS2, SPAM1 and HA receptors CD44, RHAMM/HMMR and TLR2) are discussed in terms of their known functions in wound healing and in breast cancer progression. Finally, we discuss recent advances in the use of HA-based platforms for developing nanoprobes to image areas of active HA metabolism and for therapeutics in breast cancer.

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Year:  2011        PMID： 21264398     DOI： 10.1039/c0ib00096e

Source DB:  PubMed          Journal:  Integr Biol (Camb)        ISSN： 1757-9694            Impact factor:   2.192


  18 in total

1.  Imaging of homeostatic, neoplastic, and injured tissues by HA-based probes.

Authors:  Mandana Veiseh; Daniel Breadner; Jenny Ma; Natalia Akentieva; Rashmin C Savani; Rene Harrison; David Mikilus; Lisa Collis; Stefan Gustafson; Ting-Yim Lee; James Koropatnick; Leonard G Luyt; Mina J Bissell; Eva A Turley
Journal:  Biomacromolecules       Date:  2011-12-12       Impact factor: 6.988

2.  Porous chitosan-hyaluronic acid scaffolds as a mimic of glioblastoma microenvironment ECM.

Authors:  Stephen J Florczyk; Kui Wang; Soumen Jana; David L Wood; Samara K Sytsma; Jonathan Sham; Forrest M Kievit; Miqin Zhang
Journal:  Biomaterials       Date:  2013-09-26       Impact factor: 12.479

3.  A RHAMM mimetic peptide blocks hyaluronan signaling and reduces inflammation and fibrogenesis in excisional skin wounds.

Authors:  Cornelia Tolg; Sara R Hamilton; Ewa Zalinska; Lori McCulloch; Ripal Amin; Natalia Akentieva; Francoise Winnik; Rashmin Savani; Darius J Bagli; Len G Luyt; Mary K Cowman; Jim B McCarthy; Eva A Turley
Journal:  Am J Pathol       Date:  2012-08-11       Impact factor: 4.307

4.  Activation of the FGFR-STAT3 pathway in breast cancer cells induces a hyaluronan-rich microenvironment that licenses tumor formation.

Authors:  Laura R Bohrer; Pavlina Chuntova; Lindsey K Bade; Thomas C Beadnell; Ronald P Leon; Nicholas J Brady; Yungil Ryu; Jodi E Goldberg; Stephen C Schmechel; Joseph S Koopmeiners; James B McCarthy; Kathryn L Schwertfeger
Journal:  Cancer Res       Date:  2013-11-06       Impact factor: 12.701

5.  Cellular heterogeneity profiling by hyaluronan probes reveals an invasive but slow-growing breast tumor subset.

Authors:  Mandana Veiseh; Daniel H Kwon; Alexander D Borowsky; Cornelia Tolg; Hon S Leong; John D Lewis; Eva A Turley; Mina J Bissell
Journal:  Proc Natl Acad Sci U S A       Date:  2014-04-14       Impact factor: 11.205

6.  Identification, design and synthesis of tubulin-derived peptides as novel hyaluronan mimetic ligands for the receptor for hyaluronan-mediated motility (RHAMM/HMMR).

Authors:  Kenneth Virgel N Esguerra; Cornelia Tolg; Natalia Akentieva; Matthew Price; Choi-Fong Cho; John D Lewis; James B McCarthy; Eva A Turley; Leonard G Luyt
Journal:  Integr Biol (Camb)       Date:  2015-10-12       Impact factor: 2.192

7.  Fabrication and Characterization of Chitosan-Hyaluronic Acid Scaffolds with Varying Stiffness for Glioblastoma Cell Culture.

Authors:  Ariane E Erickson; Sheeny K Lan Levengood; Jialu Sun; Fei-Chien Chang; Miqin Zhang
Journal:  Adv Healthc Mater       Date:  2018-06-11       Impact factor: 9.933

8.  Amine-modified hyaluronic acid-functionalized porous silicon nanoparticles for targeting breast cancer tumors.

Authors:  Patrick V Almeida; Mohammad-Ali Shahbazi; Ermei Mäkilä; Martti Kaasalainen; Jarno Salonen; Jouni Hirvonen; Hélder A Santos
Journal:  Nanoscale       Date:  2014-09-07       Impact factor: 7.790

9.  Intracellular Survival of Leishmania major Depends on Uptake and Degradation of Extracellular Matrix Glycosaminoglycans by Macrophages.

Authors:  Thomas Naderer; Joanne Heng; Eleanor C Saunders; Joachim Kloehn; Thusitha W Rupasinghe; Tracey J Brown; Malcolm J McConville
Journal:  PLoS Pathog       Date:  2015-09-03       Impact factor: 6.823

10.  Uncovering the dual role of RHAMM as an HA receptor and a regulator of CD44 expression in RHAMM-expressing mesenchymal progenitor cells.

Authors:  Mandana Veiseh; Sean J Leith; Cornelia Tolg; Sallie S Elhayek; S Bahram Bahrami; Lisa Collis; Sara Hamilton; James B McCarthy; Mina J Bissell; Eva Turley
Journal:  Front Cell Dev Biol       Date:  2015-10-15
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