The principles and practice of anticoagulant therapy.

The author describes the clinical rationale and pharmacology of current anticoagulant therapy. He goes on to discuss the intensity of therapy by means of oral anticoagulants, the means of monitoring this therapy, and the standardization of monitoring procedures. He also describes the indications for and best means of administering and monitoring heparin therapy, together with the major clinical indications for both heparin and oral anticoagulant therapy.