OBJECTIVE: Data show that after the implementation of routine rotavirus vaccination for infants in the United States, community-acquired (CA) rotavirus cases declined substantially in the 2007-2008 season. The impact of community-based rotavirus vaccination on the substantial burden of hospital-acquired (HA) rotavirus has not been documented. PATIENTS AND METHODS: We assessed CA and HA rotavirus, respiratory syncytial virus, and influenza infections at Children's Memorial Hospital for 5 winter seasons (defined as occurring from September through May) from 2003 to 2008. We also report rotavirus data from the 2008-2009 season. RESULTS: A similar dramatic decline (>60% compared with the median of previous seasons) occurred in the rates of cases of both CA (P < .0001) rotavirus hospitalizations and HA (P < .01) rotavirus infections in the 2007-2008 season compared with previous seasons, whereas the rates of CA and HA influenza and respiratory syncytial virus, respectively, remained stable. Improvements in hand-hygiene compliance did not correlate with a reduction in the transmission rate of rotavirus in the hospital. Both CA and HA rotavirus rates remained much lower in the 2008-2009 than in the 2003-2007 seasons. CONCLUSIONS: Community-based rotavirus vaccination is associated with a substantial reduction in the number of children who are admitted with rotavirus. These data also indicate that routine community-based rotavirus infant vaccination protects hospitalized children from acquiring rotavirus. Vaccination efforts should be encouraged as a strategy to affect the substantial burden of HA rotavirus.
OBJECTIVE: Data show that after the implementation of routine rotavirus vaccination for infants in the United States, community-acquired (CA) rotavirus cases declined substantially in the 2007-2008 season. The impact of community-based rotavirus vaccination on the substantial burden of hospital-acquired (HA) rotavirus has not been documented. PATIENTS AND METHODS: We assessed CA and HA rotavirus, respiratory syncytial virus, and influenza infections at Children's Memorial Hospital for 5 winter seasons (defined as occurring from September through May) from 2003 to 2008. We also report rotavirus data from the 2008-2009 season. RESULTS: A similar dramatic decline (>60% compared with the median of previous seasons) occurred in the rates of cases of both CA (P < .0001) rotavirus hospitalizations and HA (P < .01) rotavirus infections in the 2007-2008 season compared with previous seasons, whereas the rates of CA and HA influenza and respiratory syncytial virus, respectively, remained stable. Improvements in hand-hygiene compliance did not correlate with a reduction in the transmission rate of rotavirus in the hospital. Both CA and HA rotavirus rates remained much lower in the 2008-2009 than in the 2003-2007 seasons. CONCLUSIONS: Community-based rotavirus vaccination is associated with a substantial reduction in the number of children who are admitted with rotavirus. These data also indicate that routine community-based rotavirus infant vaccination protects hospitalized children from acquiring rotavirus. Vaccination efforts should be encouraged as a strategy to affect the substantial burden of HA rotavirus.
Authors: Catherine Yen; Jacqueline E Tate; Terri B Hyde; Margaret M Cortese; Benjamin A Lopman; Baoming Jiang; Roger I Glass; Umesh D Parashar Journal: Hum Vaccin Immunother Date: 2014-04-22 Impact factor: 3.452
Authors: Venkata Raghava Mohan; Ramanujam Karthikeyan; Sudhir Babji; Monica McGrath; Sanjaya Shrestha; Jasmin Shrestha; Estomih Mdumah; Caroline Amour; Amidou Samie; Emanuel Nyathi; Rashidul Haque; Shahida Qureshi; Pablo Peñataro Yori; Aldo A M Lima; Ladaporn Bodhidatta; Erling Svensen; Pascal Bessong; Tahmeed Ahmed; Jessica C Seidman; Anita K M Zaidi; Margaret N Kosek; Richard L Guerrant; Jean Gratz; James A Platts-Mills; Dennis R Lang; Michael Gottlieb; Eric R Houpt; Gagandeep Kang Journal: J Infect Dis Date: 2017-08-01 Impact factor: 5.226
Authors: Angel Herrera Guerra; Chris Stockmann; Andrew T Pavia; Adam L Hersh; Emily A Thorell; Hsin Yi Weng; Kent Korgenski; Carrie L Byington; Krow Ampofo Journal: J Pediatric Infect Dis Soc Date: 2012-06-22 Impact factor: 3.164
Authors: Sylvain Bernard; Louis Valiquette; Philippe De Wals; Vincent Nault; Corentin Babakissa; Claude Cyr; Thérèse Côté Boileau; Arnaud Gagneur Journal: Can J Infect Dis Med Microbiol Date: 2013 Impact factor: 2.471
Authors: Guadalupe González-Ochoa; Griselda E Menchaca; Carlos E Hernández; Cristina Rodríguez; Reyes S Tamez; Juan F Contreras Journal: Viruses Date: 2013-03-11 Impact factor: 5.048