| Literature DB >> 21262171 |
Sif Gudbrandsdottir1, Henrik Frederiksen, Henrik Sverre Birgens, Claus Henrik Nielsen, Ove Juul Nielsen, Jesper Stentoft, Hans Carl Hasselbalch.
Abstract
Primary immune thrombocytopenia (ITP)--formerly known as idiopathic thrombocytopenic purpura--is an autoimmune disorder characterized by immune mediated thrombocytopenia. The aetiology of ITP remains unknown, but studies have shown that multiple immunological mechanisms are involved in the pathogenesis of ITP. This article aims to provide an overview of current treatment options, with particular emphasis on new biological therapies: rituximab, a monoclonal anti-CD20 antibody, and the thrombopoietin receptor agonists romiplostim and eltrombopag.Entities:
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Year: 2011 PMID: 21262171
Source DB: PubMed Journal: Ugeskr Laeger ISSN: 0041-5782