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Literature DB >> 2126177

Identification of a plasminogen activator derived from nasopharyngeal carcinoma.

T Kosugi¹, G W Huang, M Nakamura, S Koja, H T Nong.

Abstract

The activity of plasminogen activator (PA) in tissue extracts from nasopharyngeal carcinoma (NPC) was determined by means of the fibrin plate method. Development of PA activity was observed in 16 out of 25 cases investigated. Furthermore, using tissue extract of NPC with PA activity, characterization and identification of the activator were carried out by means of electrophoretic analysis, fibrin zymography and immunological analysis. The molecular weight of this PA was found to be 38,000 daltons. Additionally, a urokinase type of plasminogen activator was contained in the tissue extracts.

Entities: Disease

Mesh：

Substances：

Year: 1990 PMID： 2126177 DOI： 10.1007/bf00179011

Source DB: PubMed Journal: Eur Arch Otorhinolaryngol ISSN： 0937-4477 Impact factor: 2.503

42 in total

1. Effect of human plasmin on the toxic effects and growth of blood borne metastatis of the Brown-Pearce carcinoma and the V2 carcinoma of rabbit.

Authors: E E CLIFFTON; C E GROSSI
Journal: Cancer Date: 1956 Nov-Dec Impact factor: 6.860

2. Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors: U K Laemmli
Journal: Nature Date: 1970-08-15 Impact factor: 49.962

3. Platelet release protein which inhibits plasminogen activators.

Authors: N A Booth; J A Anderson; B Bennett
Journal: J Clin Pathol Date: 1985-07 Impact factor: 3.411

4. Plasminogen activator activity and composition in human breast cancer.

Authors: J L Evers; J Patel; J M Madeja; S L Schneider; G H Hobika; S M Camiolo; G Markus
Journal: Cancer Res Date: 1982-01 Impact factor: 12.701

5. [Studies of tonsillitis from the aspect of protease-antiprotease. 2. Substances relation to fibrinolysis in tonsillar tissue of man (author's transl)].

Authors: T Kosugi; M Hamaya
Journal: Nihon Jibiinkoka Gakkai Kaiho Date: 1978-04-20

Review 6. Plasminogen activator and cancer.

Authors: M J Duffy; P O'Grady
Journal: Eur J Cancer Clin Oncol Date: 1984-05

Identification of a plasminogen activator derived from nasopharyngeal carcinoma.

1. Effect of human plasmin on the toxic effects and growth of blood borne metastatis of the Brown-Pearce carcinoma and the V2 carcinoma of rabbit.

2. Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

3. Platelet release protein which inhibits plasminogen activators.

4. Plasminogen activator activity and composition in human breast cancer.

5. [Studies of tonsillitis from the aspect of protease-antiprotease. 2. Substances relation to fibrinolysis in tonsillar tissue of man (author's transl)].

Review 6. Plasminogen activator and cancer.

7. Antibodies to plasminogen activator inhibit human tumor metastasis.

8. Isolation from human plasma of a plasminogen activator identical to urinary high molecular weight urokinase.

9. Serine enzymes released by cultured neoplastic cells.

10. A study of proteases and protease-inhibitor complexes in biological fluids.

1. The concentration of u-PA and PAI-1 antigen in tissue extracts of nasopharyngeal carcinoma.