BACKGROUND AND AIM: Carriage of the apolipoprotein E (Apo E) variants, E2, E3 and E4, affects cholesterol metabolism and may be involved in the persistence of hepatitis C virus (HCV) infection. Our aim was to verify whether carriage of specific Apo E variants modulates the course of hepatitis C. METHODS: We studied a cohort of 116 HCV-positive patients (49 male subjects) with persistently normal transaminases and an Ishak staging score ≤ 2 at an initial biopsy. These untreated patients underwent regular clinical monitoring (median histological follow up: 10 years). Apo E variants were genotyped and results were related to the histological outcome. RESULTS: The mean ± standard deviation staging scores were 0.9 ± 0.7 at entry versus 1.9 ± 1.2 at the end of follow up, P < 0.0001. Initial and final staging scores in the E3/E3 homozygotes (n = 74) were 1.0 ± 0.7 versus 2.1 ± 1.3, P < 0.0001, while in the remaining patients (n = 42) they were 0.9 ± 0.6 versus 1.5 ± 1.0, P < 0.002. A synergistic effect was observed between Apo E polymorphisms and baseline serum cholesterol values: patients not carrying any E3 allele, as well as carriers of a single E3 allele with serum cholesterol concentration > 190 mg/dL were more likely to have a favorable outcome (final vs initial staging score increased in 7/66, did not change in 10/46, and decreased in 3/4, P <0.005). CONCLUSIONS: Some of the variability in the natural history of patients with persistently normal transaminases with initially mild hepatitis C can be related to their Apo E genetic background.
BACKGROUND AND AIM: Carriage of the apolipoprotein E (Apo E) variants, E2, E3 and E4, affects cholesterol metabolism and may be involved in the persistence of hepatitis C virus (HCV) infection. Our aim was to verify whether carriage of specific Apo E variants modulates the course of hepatitis C. METHODS: We studied a cohort of 116 HCV-positive patients (49 male subjects) with persistently normal transaminases and an Ishak staging score ≤ 2 at an initial biopsy. These untreated patients underwent regular clinical monitoring (median histological follow up: 10 years). Apo E variants were genotyped and results were related to the histological outcome. RESULTS: The mean ± standard deviation staging scores were 0.9 ± 0.7 at entry versus 1.9 ± 1.2 at the end of follow up, P < 0.0001. Initial and final staging scores in the E3/E3 homozygotes (n = 74) were 1.0 ± 0.7 versus 2.1 ± 1.3, P < 0.0001, while in the remaining patients (n = 42) they were 0.9 ± 0.6 versus 1.5 ± 1.0, P < 0.002. A synergistic effect was observed between Apo E polymorphisms and baseline serum cholesterol values: patients not carrying any E3 allele, as well as carriers of a single E3 allele with serum cholesterol concentration > 190 mg/dL were more likely to have a favorable outcome (final vs initial staging score increased in 7/66, did not change in 10/46, and decreased in 3/4, P <0.005). CONCLUSIONS: Some of the variability in the natural history of patients with persistently normal transaminases with initially mild hepatitis C can be related to their Apo E genetic background.
Authors: José Carlos Rodrigues Nascimento; Lianna C Pereira; Juliana Magalhães C Rêgo; Ronaldo P Dias; Paulo Goberlânio B Silva; Silvio Alencar C Sobrinho; Gustavo R Coelho; Ivelise Regina C Brasil; Edmilson F Oliveira-Filho; James S Owen; Pierluigi Toniutto; Reinaldo B Oriá Journal: World J Gastroenterol Date: 2021-03-21 Impact factor: 5.742
Authors: Amr Ali Hemeda; Amal Ahmad Mohamed; Ramy Karam Aziz; Mohamed S Abdel-Hakeem; Marwa Ali-Tammam Journal: Viruses Date: 2021-04-20 Impact factor: 5.048
Authors: Caíque Silveira Martins da Fonseca; Adenor Almeida Pimenta Filho; Bianka Santana dos Santos; César Augusto da Silva; Ana Lúcia Coutinho Domingues; James Stuart Owen; Vera Lúcia de Menezes Lima Journal: PLoS One Date: 2014-07-22 Impact factor: 3.240
Authors: Chen Zhao; Kevin Strobino; Yeseon Park Moon; Ying Kuen Cheung; Ralph L Sacco; Yaakov Stern; Mitchell S V Elkind Journal: Neurol Genet Date: 2020-07-07