Literature DB >> 21261476

SMARCA5 methylation and expression in gastric cancer.

Carolina Oliveira Gigek1, Luara Carolina Frias Lisboa, Mariana Ferreira Leal, Patricia Natalia Oliveira Silva, Eleonidas Moura Lima, André Salim Khayat, Paulo Pimentel Assumpção, Rommel Rodriguez Burbano, Marilia de Arruda Cardoso Smith.   

Abstract

Here, we first evaluated SMARCA5 expression and promoter DNA methylation in gastric carcinogenesis. Immunohistochemistry and methylation-specific PCR were analyzed in 19 and 48 normal mucosa and in 52 and 92 gastric cancer samples, respectively. We observed higher immunoreactivity of SMARCA5 in gastric cancer samples than in normal mucosa. Moreover, SMARCA5 promoter methylation was associated with the absence of protein expression. Our findings suggest that SMARCA5 has a potential role in proliferation and malignancy in gastric carcinogenesis.

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Year:  2011        PMID： 21261476     DOI： 10.3109/07357907.2010.543365

Source DB:  PubMed          Journal:  Cancer Invest        ISSN： 0735-7907            Impact factor:   2.176


  21 in total

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