Literature DB >> 2125988

Recognition of the polypeptide core of mucin by monoclonal antibody MUSE11 against an adenocarcinoma-associated antigen.

Y Hinoda1, N Nakagawa, Y Ohe, H Kakiuchi, M Tsujisaki, K Imai, A Yachi.   

Abstract

Monoclonal antibody (MAb) MUSE11 detects an adenocarcinoma-associated antigen and is useful for the serodiagnosis of pancreas cancer. We established a sandwich enzyme immunoassay using MAb MUSE11 and MAb DF3 against a breast cancer-associated mucin core protein as a catcher and a tracer, respectively. With this assay system, the binding of the tracer MAb DF3 to an antigen in the human kidney tissue lysate was clearly inhibited by MAb MUSE11. In addition, MAb MUSE11 showed a significant binding activity to the synthetic peptide corresponding to the tandem repeat of a human epithelial mucin core protein. These data suggest that MAb MUSE11 could detect the polypeptide core of a mucin, and may be of use for studying mucin as a gene product.

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Year:  1990        PMID： 2125988      PMCID： PMC5917999          DOI： 10.1111/j.1349-7006.1990.tb02679.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


monoclonal antibody enzyme immunoassay carcinoembryonic antigen complementary DNA
  24 in total

1.  Analysis of a human tumor-associated glycoprotein (TAG-72) identified by monoclonal antibody B72.3.

Authors:  V G Johnson; J Schlom; A J Paterson; J Bennett; J L Magnani; D Colcher
Journal:  Cancer Res       Date:  1986-02       Impact factor: 12.701

2.  A sandwich enzyme immunoassay of an adenocarcinoma-associated antigen, YH206, in cancer sera.

Authors:  Y Hinoda; K Imai; T Ban; T Endo; A Yachi
Journal:  Jpn J Cancer Res       Date:  1987-06

3.  A short sequence, within the amino acid tandem repeat of a cancer-associated mucin, contains immunodominant epitopes.

Authors:  J Burchell; J Taylor-Papadimitriou; M Boshell; S Gendler; T Duhig
Journal:  Int J Cancer       Date:  1989-10-15       Impact factor: 7.396

4.  Frequent alteration of the DF3 tumor-associated antigen gene in primary human breast carcinomas.

Authors:  G R Merlo; J Siddiqui; C S Cropp; D S Liscia; R Lidereau; R Callahan; D W Kufe
Journal:  Cancer Res       Date:  1989-12-15       Impact factor: 12.701

5.  Purification and characterization of a high molecular weight glycoprotein detectable in human milk and breast carcinomas.

Authors:  H Sekine; T Ohno; D W Kufe
Journal:  J Immunol       Date:  1985-11       Impact factor: 5.422

6.  The detection of human pancreatic cancer-associated antigen in the serum of cancer patients.

Authors:  Y S Chung; J J Ho; Y S Kim; H Tanaka; B Nakata; A Hiura; H Motoyoshi; K Satake; K Umeyama
Journal:  Cancer       Date:  1987-10-01       Impact factor: 6.860

7.  Immunochemical characterization of adenocarcinoma-associated antigen YH206.

Authors:  Y Hinoda; K Imai; T Ban; T Endo; A Yachi
Journal:  Int J Cancer       Date:  1988-11-15       Impact factor: 7.396

8.  A monoclonal antibody-defined antigen associated with gastrointestinal cancer is a ganglioside containing sialylated lacto-N-fucopentaose II.

Authors:  J L Magnani; B Nilsson; M Brockhaus; D Zopf; Z Steplewski; H Koprowski; V Ginsburg
Journal:  J Biol Chem       Date:  1982-12-10       Impact factor: 5.157

9.  Monoclonal antibodies against gastrointestinal tumour-associated antigens isolated as monosialogangliosides.

Authors:  L Lindholm; J Holmgren; L Svennerholm; P Fredman; O Nilsson; B Persson; H Myrvold; T Lagergård
Journal:  Int Arch Allergy Appl Immunol       Date:  1983

10.  Tissue distribution of an epithelial and tumor-associated antigen recognized by monoclonal antibody F36/22.

Authors:  G A Croghan; L D Papsidero; L A Valenzuela; T Nemoto; R Penetrante; T M Chu
Journal:  Cancer Res       Date:  1983-10       Impact factor: 12.701
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  7 in total

1.  MUC1 and MUC2 mucins in flat and polypoid colorectal adenomas.

Authors:  Y Ajioka; H Watanabe; J R Jass
Journal:  J Clin Pathol       Date:  1997-05       Impact factor: 3.411

2.  Circulating tumor-associated antigens detected by monoclonal antibodies against the polypeptide core of mucin--comparison of antigen MUSE11 with CA15-3.

Authors:  Y Hinoda; H Kakiuchi; N Nakagawa; Y Ohe; T Sugiyama; M Tsujisaki; K Imai; A Yachi
Journal:  Gastroenterol Jpn       Date:  1992-06

3.  Apical MUC1 expression revealed on the foveolar epithelium in H. pylori gastritis.

Authors:  M Rashid; A S Teixeira; U Qureshi; S P Pereira; M R Novelli; D M Swallow
Journal:  Br J Cancer       Date:  2013-02-14       Impact factor: 7.640

Review 4.  Potential of Anti-MUC1 Antibodies as a Targeted Therapy for Gastrointestinal Cancers.

Authors:  Mukulika Bose; Pinku Mukherjee
Journal:  Vaccines (Basel)       Date:  2020-11-05

5.  A new serum tumor marker, CAM 123-6, highly specific to pulmonary adenocarcinoma.

Authors:  H Hamada; N Kohno; K Hiwada
Journal:  Jpn J Cancer Res       Date:  1994-02

6.  Expression of sulfated carbohydrate chains detected by monoclonal antibody 91.9H in human gastric cancer tissues.

Authors:  Y Ohe; Y Hinoda; T Irimura; K Imai; A Yachi
Journal:  Jpn J Cancer Res       Date:  1994-04

7.  Effect of MUC1 mucin, an anti-adhesion molecule, on tumor cell growth.

Authors:  Y Makiguchi; Y Hinoda; K Imai
Journal:  Jpn J Cancer Res       Date:  1996-05
  7 in total

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