Literature DB >> 2125987

Detection of the c-myc gene product in urinary bladder cancer.

T Kotake1, S Saiki, T Kinouchi, H Shiku, E Nakayama.   

Abstract

Expression of the c-myc gene product in urinary bladder cancer was investigated by immunohistochemical staining with anti-c-myc monoclonal antibody (mAb) MYC-1. Positive staining was observed in the cytoplasm, but not in the nucleus in tissues fixed with 10% formalin. On the other hand, positive staining was localized in the nucleus in cryopreserved tissues. Of 34 cryopreserved specimens examined, positive staining with MYC-1 mAb was observed in 1 of 12 (8.3%) of grade 1 (G1), 12 of 15 (80%) of G2 and 6 of 7 (86%) of G3. Positive staining with Ki-67 mAb was observed in 2 of 12 (17%) of G1, 12 of 15 (80%) of G2, and 6 of 7 (86%) of G3. These results suggest that tumors with higher nuclear pleomorphism contain more proliferating cells.

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Year:  1990        PMID： 2125987      PMCID： PMC5918014          DOI： 10.1111/j.1349-7006.1990.tb02677.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


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Journal:  Cell       Date:  1983-12       Impact factor: 41.582

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Authors:  T Naoe; N Nozaki; K Yamada; T Okazaki; E Nakayama; Y Kurosawa; H Shiku
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  11 in total

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Authors:  Stephen G Williams; John P Stein
Journal:  Urol Res       Date:  2004-11-13

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Authors:  Isis G A Kiehl; Eduardo Riccetto; Ana C C Salustiano; Marina V Ossick; Karen L Ferrari; Heloisa B Assalin; Osamu Ikari; Leonardo O Reis
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Journal:  Urologe A       Date:  2009-06       Impact factor: 0.639

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9.  CEBPD amplification and overexpression in urothelial carcinoma: a driver of tumor metastasis indicating adverse prognosis.

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10.  The establishment of a growth-controllable orthotopic bladder cancer model through the down-regulation of c-myc expression.

Authors:  Ho Kyung Seo; Seung-Phil Shin; Na-Rae Jung; Whi-An Kwon; Kyung-Chae Jeong; Sang-Jin Lee
Journal:  Oncotarget       Date:  2016-07-22
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