Literature DB >> 2125986

X protein of hepatitis B virus resembles a serine protease inhibitor.

S Takada1, K Koike.   

Abstract

The X protein of hepatitis B virus (HBV) has been shown to be a trans-activator for viral and cellular genes. Amino acid sequences in X protein were found to be highly homologous to functionally essential sequences in the "Kunitz domain," characteristic of Kunitz-type serine protease inhibitors. Mutations at these sequences completely abolished trans-activation. Consequently, HBV X protein resembles a serine protease inhibitor or its analogue, and may bring about trans-activation by activating certain transcriptional factors through proteolytic cleavage alteration.

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Year:  1990        PMID： 2125986      PMCID： PMC5918017          DOI： 10.1111/j.1349-7006.1990.tb02675.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


  25 in total

1.  trans-activation of viral enhancers by the hepatitis B virus X protein.

Authors:  D F Spandau; C H Lee
Journal:  J Virol       Date:  1988-02       Impact factor: 5.103

2.  A growth-responsive gene (16C8) in normal mouse fibroblasts homologous to a human collagenase inhibitor with erythroid-potentiating activity: evidence for inducible and constitutive transcripts.

Authors:  D R Edwards; P Waterhouse; M L Holman; D T Denhardt
Journal:  Nucleic Acids Res       Date:  1986-11-25       Impact factor: 16.971

3.  Transcriptional activation of homologous and heterologous genes by the hepatitis B virus X gene product in cells permissive for viral replication.

Authors:  R Colgrove; G Simon; D Ganem
Journal:  J Virol       Date:  1989-09       Impact factor: 5.103

4.  The mouse c-abl locus: molecular cloning and characterization.

Authors:  J Y Wang; F Ledley; S Goff; R Lee; Y Groner; D Baltimore
Journal:  Cell       Date:  1984-02       Impact factor: 41.582

Review 5.  Protein inhibitors of proteinases.

Authors:  M Laskowski; I Kato
Journal:  Annu Rev Biochem       Date:  1980       Impact factor: 23.643

6.  Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice.

Authors:  F V Chisari; K Klopchin; T Moriyama; C Pasquinelli; H A Dunsford; S Sell; C A Pinkert; R L Brinster; R D Palmiter
Journal:  Cell       Date:  1989-12-22       Impact factor: 41.582

7.  Nucleotide sequence of a cloned duck hepatitis B virus genome: comparison with woodchuck and human hepatitis B virus sequences.

Authors:  E Mandart; A Kay; F Galibert
Journal:  J Virol       Date:  1984-03       Impact factor: 5.103

8.  Isolation of a genomic clone for bovine pancreatic trypsin inhibitor by using a unique-sequence synthetic DNA probe.

Authors:  S Anderson; I B Kingston
Journal:  Proc Natl Acad Sci U S A       Date:  1983-11       Impact factor: 11.205

9.  The amino acid sequence of a weak trypsin inhibitor B from Dendroaspis Polylepis polylepis (black mamba) venom.

Authors:  D J Strydom; F J Joubert
Journal:  Hoppe Seylers Z Physiol Chem       Date:  1981-10

10.  Nucleotide sequence of Abelson murine leukemia virus genome: structural similarity of its transforming gene product to other onc gene products with tyrosine-specific kinase activity.

Authors:  E P Reddy; M J Smith; A Srinivasan
Journal:  Proc Natl Acad Sci U S A       Date:  1983-06       Impact factor: 11.205
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  14 in total

Review 1.  Clinical aspects and epidemiology of hepatitis B and C viruses in hepatocellular carcinoma in Japan.

Authors:  K Kiyosawa; S Furuta
Journal:  Cancer Chemother Pharmacol       Date:  1992       Impact factor: 3.333

Review 2.  Hepatitis B virus biology.

Authors:  C Seeger; W S Mason
Journal:  Microbiol Mol Biol Rev       Date:  2000-03       Impact factor: 11.056

3.  Disruption of the function of tumor-suppressor gene p53 by the hepatitis B virus X protein and hepatocarcinogenesis.

Authors:  S Takada; N Tsuchida; M Kobayashi; K Koike
Journal:  J Cancer Res Clin Oncol       Date:  1995       Impact factor: 4.553

4.  The X protein of hepatitis B virus coactivates potent activation domains.

Authors:  I Haviv; D Vaizel; Y Shaul
Journal:  Mol Cell Biol       Date:  1995-02       Impact factor: 4.272

5.  Proteasome complex as a potential cellular target of hepatitis B virus X protein.

Authors:  J Huang; J Kwong; E C Sun; T J Liang
Journal:  J Virol       Date:  1996-08       Impact factor: 5.103

Review 6.  Hepatitis B virus and hepatocellular carcinoma.

Authors:  P Arbuthnot; M Kew
Journal:  Int J Exp Pathol       Date:  2001-04       Impact factor: 1.925

7.  A new hepadnavirus endemic in arctic ground squirrels in Alaska.

Authors:  P Testut; C A Renard; O Terradillos; L Vitvitski-Trepo; F Tekaia; C Degott; J Blake; B Boyer; M A Buendia
Journal:  J Virol       Date:  1996-07       Impact factor: 5.103

Review 8.  Hepatitis B virus X antigen in the pathogenesis of chronic infections and the development of hepatocellular carcinoma.

Authors:  M A Feitelson; L X Duan
Journal:  Am J Pathol       Date:  1997-04       Impact factor: 4.307

9.  The woodchuck hepatitis virus X gene is important for establishment of virus infection in woodchucks.

Authors:  H S Chen; S Kaneko; R Girones; R W Anderson; W E Hornbuckle; B C Tennant; P J Cote; J L Gerin; R H Purcell; R H Miller
Journal:  J Virol       Date:  1993-03       Impact factor: 5.103

10.  Hepatitis B virus X protein interacts with a probable cellular DNA repair protein.

Authors:  T H Lee; S J Elledge; J S Butel
Journal:  J Virol       Date:  1995-02       Impact factor: 5.103
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