M Inal1, A Dokumacioglu, E Özcelik, O Ucar. 1. Department of Biochemistry, Medicine Faculty, Osmangazi University, 26480 Meselik, Eskisehir, Turkey. minal@ogu.edu.tr
Abstract
BACKGROUND: Ozone therapy is employed as a therapeutic agent in various diseases. Since ozone itself is a radical, using a small dosage of it is known to create an oxidative preconditioning in the body and trigger a strong antioxidant response against that. Coenzyme Q(10), as a strong antioxidant agent, is delivered as a supportive factor in many diseases involving oxidative stress. AIM: The aim of the study was to evaluate the effects of the combination treatment over oxidative stress in healthy individuals. METHODS: In the current study, 11 healthy volunteers were administered a combination of ozone therapy and Q(10) for 1 month. Blood samples were collected first right after the initial ozone therapy and then 1 month after the ozone therapy + coenzyme Q(10) treatment. We measured erythrocyte superoxide dismutase and catalase enzyme activities along with serum malondialdehyde levels. RESULTS: Compared with the pretreatment values, an increase was determined in the erythrocyte superoxide dismutase and catalase enzyme activities. However, malondialdehyde, an indicator of oxidative membrane damage, showed a reduction after the combination treatment. CONCLUSION: The results of this study reveal the beneficial effects of ozone therapy + coenzyme Q(10) combination in prevention of oxidative damage.
BACKGROUND: Ozone therapy is employed as a therapeutic agent in various diseases. Since ozone itself is a radical, using a small dosage of it is known to create an oxidative preconditioning in the body and trigger a strong antioxidant response against that. Coenzyme Q(10), as a strong antioxidant agent, is delivered as a supportive factor in many diseases involving oxidative stress. AIM: The aim of the study was to evaluate the effects of the combination treatment over oxidative stress in healthy individuals. METHODS: In the current study, 11 healthy volunteers were administered a combination of ozone therapy and Q(10) for 1 month. Blood samples were collected first right after the initial ozone therapy and then 1 month after the ozone therapy + coenzyme Q(10) treatment. We measured erythrocyte superoxide dismutase and catalase enzyme activities along with serum malondialdehyde levels. RESULTS: Compared with the pretreatment values, an increase was determined in the erythrocyte superoxide dismutase and catalase enzyme activities. However, malondialdehyde, an indicator of oxidative membrane damage, showed a reduction after the combination treatment. CONCLUSION: The results of this study reveal the beneficial effects of ozone therapy + coenzyme Q(10) combination in prevention of oxidative damage.
Authors: S M Al-Dalain; G Martínez; E Candelario-Jalil; S Menéndez; L Re; A Giuliani; O S León Journal: Pharmacol Res Date: 2001-11 Impact factor: 7.658
Authors: Pawel Madej; Andrzej Plewka; Janusz A Madej; Marcin Nowak; Danuta Plewka; Grzegorz Franik; Darek Golka Journal: Inflammation Date: 2007-02-14 Impact factor: 4.092
Authors: Linda K Kwong; Sergey Kamzalov; Igor Rebrin; Anne-Cécile V Bayne; Chandan K Jana; Paul Morris; Michael J Forster; Rajindar S Sohal Journal: Free Radic Biol Med Date: 2002-09-01 Impact factor: 7.376
Authors: Tao Qiu; Zhi-Shun Wang; Xiu-Heng Liu; Hui Chen; Jiang-Qiao Zhou; Zhi-Yuan Chen; Min Wang; Guan-Jun Jiang; Lei Wang; Gang Yu; Long Zhang; Ye Shen; Lu Zhang; Li He; Hua-Xin Wang; Wen-Jing Zhang Journal: Exp Ther Med Date: 2017-03-08 Impact factor: 2.447
Authors: Alessandro de Sire; Francesco Agostini; Lorenzo Lippi; Massimiliano Mangone; Simone Marchese; Carlo Cisari; Andrea Bernetti; Marco Invernizzi Journal: Biomolecules Date: 2021-02-26