Literature DB >> 21257778

Cholesterol is not an essential source of nutrition for Mycobacterium tuberculosis during infection.

Xinxin Yang1, Jin Gao, Issar Smith, Eugenie Dubnau, Nicole S Sampson.   

Abstract

Rv1106c (hsd; 3β-hydroxysteroid dehydrogenase) is required by Mycobacterium tuberculosis for growth on cholesterol as a sole carbon source, whereas Rv3409c is not. Mutation of Rv1106c does not reduce Mycobacterium tuberculosis growth in infected macrophages or guinea pigs. We conclude that cholesterol is not required as a nutritional source during infection.

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Year:  2011        PMID： 21257778      PMCID： PMC3067635          DOI： 10.1128/JB.01210-10

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  27 in total

1.  Mycobacterium tuberculosis is able to accumulate and utilize cholesterol.

Authors:  Anna Brzostek; Jakub Pawelczyk; Anna Rumijowska-Galewicz; Bozena Dziadek; Jaroslaw Dziadek
Journal:  J Bacteriol       Date:  2009-08-28       Impact factor: 3.490

2.  Cytochrome P450 125 (CYP125) catalyses C26-hydroxylation to initiate sterol side-chain degradation in Rhodococcus jostii RHA1.

Authors:  Kamila Z Rosłoniec; Maarten H Wilbrink; Jenna K Capyk; William W Mohn; Martin Ostendorf; Robert van der Geize; Lubbert Dijkhuizen; Lindsay D Eltis
Journal:  Mol Microbiol       Date:  2009-10-15       Impact factor: 3.501

Review 3.  Cholesterol oxidase: physiological functions.

Authors:  Joseph Kreit; Nicole S Sampson
Journal:  FEBS J       Date:  2009-10-16       Impact factor: 5.542

4.  Mycobacterial persistence requires the utilization of host cholesterol.

Authors:  Amit K Pandey; Christopher M Sassetti
Journal:  Proc Natl Acad Sci U S A       Date:  2008-03-11       Impact factor: 11.205

5.  A thiolase of Mycobacterium tuberculosis is required for virulence and production of androstenedione and androstadienedione from cholesterol.

Authors:  Natasha M Nesbitt; Xinxin Yang; Patricia Fontán; Irina Kolesnikova; Issar Smith; Nicole S Sampson; Eugenie Dubnau
Journal:  Infect Immun       Date:  2009-10-12       Impact factor: 3.441

6.  Cholesterol oxidase is required for virulence of Mycobacterium tuberculosis.

Authors:  Anna Brzostek; Bozena Dziadek; Anna Rumijowska-Galewicz; Jakub Pawelczyk; Jaroslaw Dziadek
Journal:  FEMS Microbiol Lett       Date:  2007-07-25       Impact factor: 2.742

7.  Cholesterol metabolism increases the metabolic pool of propionate in Mycobacterium tuberculosis.

Authors:  Xinxin Yang; Natasha M Nesbitt; Eugenie Dubnau; Issar Smith; Nicole S Sampson
Journal:  Biochemistry       Date:  2009-05-12       Impact factor: 3.162

8.  igr Genes and Mycobacterium tuberculosis cholesterol metabolism.

Authors:  Jennifer C Chang; Maurine D Miner; Amit K Pandey; Wendy P Gill; Nada S Harik; Christopher M Sassetti; David R Sherman
Journal:  J Bacteriol       Date:  2009-06-19       Impact factor: 3.490

9.  Rv1106c from Mycobacterium tuberculosis is a 3beta-hydroxysteroid dehydrogenase.

Authors:  Xinxin Yang; Eugenie Dubnau; Issar Smith; Nicole S Sampson
Journal:  Biochemistry       Date:  2007-07-14       Impact factor: 3.162

10.  Studies of a ring-cleaving dioxygenase illuminate the role of cholesterol metabolism in the pathogenesis of Mycobacterium tuberculosis.

Authors:  Katherine C Yam; Igor D'Angelo; Rainer Kalscheuer; Haizhong Zhu; Jian-Xin Wang; Victor Snieckus; Lan H Ly; Paul J Converse; William R Jacobs; Natalie Strynadka; Lindsay D Eltis
Journal:  PLoS Pathog       Date:  2009-03-20       Impact factor: 6.823
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  27 in total

1.  Mycobacterium tuberculosis cholesterol catabolism requires a new class of acyl coenzyme A dehydrogenase.

Authors:  Martin I Voskuil
Journal:  J Bacteriol       Date:  2013-07-26       Impact factor: 3.490

Review 2.  Metabolic Perspectives on Persistence.

Authors:  Travis E Hartman; Zhe Wang; Robert S Jansen; Susana Gardete; Kyu Y Rhee
Journal:  Microbiol Spectr       Date:  2017-01

Review 3.  The tuberculosis drug discovery and development pipeline and emerging drug targets.

Authors:  Khisimuzi Mdluli; Takushi Kaneko; Anna Upton
Journal:  Cold Spring Harb Perspect Med       Date:  2015-01-29       Impact factor: 6.915

Review 4.  Virulence factors of the Mycobacterium tuberculosis complex.

Authors:  Marina A Forrellad; Laura I Klepp; Andrea Gioffré; Julia Sabio y García; Hector R Morbidoni; María de la Paz Santangelo; Angel A Cataldi; Fabiana Bigi
Journal:  Virulence       Date:  2012-10-17       Impact factor: 5.882

Review 5.  Updating and curating metabolic pathways of TB.

Authors:  Richard A Slayden; Mary Jackson; Jeremy Zucker; Melissa V Ramirez; Clinton C Dawson; Rebecca Crew; Nicole S Sampson; Suzanne T Thomas; Neema Jamshidi; Peter Sisk; Ron Caspi; Dean C Crick; Michael R McNeil; Martin S Pavelka; Michael Niederweis; Axel Siroy; Valentina Dona; Johnjoe McFadden; Helena Boshoff; Jocelyne M Lew
Journal:  Tuberculosis (Edinb)       Date:  2013-02-01       Impact factor: 3.131

Review 6.  Pathogen roid rage: cholesterol utilization by Mycobacterium tuberculosis.

Authors:  Matthew F Wipperman; Nicole S Sampson; Suzanne T Thomas
Journal:  Crit Rev Biochem Mol Biol       Date:  2014-03-10       Impact factor: 8.250

Review 7.  Cholesterol catabolism as a therapeutic target in Mycobacterium tuberculosis.

Authors:  Hugues Ouellet; Jonathan B Johnston; Paul R Ortiz de Montellano
Journal:  Trends Microbiol       Date:  2011-09-15       Impact factor: 17.079

Review 8.  More than cholesterol catabolism: regulatory vulnerabilities in Mycobacterium tuberculosis.

Authors:  Amber C Bonds; Nicole S Sampson
Journal:  Curr Opin Chem Biol       Date:  2018-06-12       Impact factor: 8.822

9.  α-Methyl Acyl CoA Racemase Provides Mycobacterium tuberculosis Catabolic Access to Cholesterol Esters.

Authors:  Rui Lu; Werner Schmitz; Nicole S Sampson
Journal:  Biochemistry       Date:  2015-09-11       Impact factor: 3.162

10.  Oxadiazoles Have Butyrate-Specific Conditional Activity against Mycobacterium tuberculosis.

Authors:  Julie V Early; Allen Casey; Maria Angeles Martinez-Grau; Isabel C Gonzalez Valcarcel; Michal Vieth; Juliane Ollinger; Mai Ann Bailey; Torey Alling; Megan Files; Yulia Ovechkina; Tanya Parish
Journal:  Antimicrob Agents Chemother       Date:  2016-05-23       Impact factor: 5.191
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