Literature DB >> 21256847

Characterization of inositol phospho-sphingolipid-phospholipase C 1 (Isc1) in Cryptococcus neoformans reveals unique biochemical features.

Jennifer Henry1, Aimee Guillotte, Chiara Luberto, Maurizio Del Poeta.   

Abstract

In this work, we biochemically characterized inositol phosphosphingolipid-phospholipase C (Isc1) from the pathogenic fungus Cryptococcus neoformans. Unlike Isc1 from other fungi and parasites which hydrolyze both fungal complex sphingolipids (IPC-PLC) and mammalian sphingomyelin (SM-PLC), C. neoformans Isc1 only exerts IPC-PLC activity. Genetic mutations thought to regulate substrate recognition in other Isc1 proteins do not restore SM-PLC activity of the cryptococcal enzyme. C. neoformans Isc1 regulates the level of complex sphingolipids and certain species of phytoceramide, especially when fungal cells are exposed to acidic stress. Since growth in acidic environments is required for C. neoformans to cause disease, this study has important implications for understanding of C. neoformans pathogenicity.
Copyright © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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Year:  2011        PMID： 21256847      PMCID： PMC3045780          DOI： 10.1016/j.febslet.2011.01.015

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  29 in total

1.  Cryptococcus neoformans: intracellular or extracellular?

Authors:  S M Levitz
Journal:  Trends Microbiol       Date:  2001-09       Impact factor: 17.079

2.  A distant evolutionary relationship between bacterial sphingomyelinase and mammalian DNase I.

Authors:  Y Matsuo; A Yamada; K Tsukamoto; H Tamura; H Ikezawa; H Nakamura; K Nishikawa
Journal:  Protein Sci       Date:  1996-12       Impact factor: 6.725

3.  Cryptococcus neoformans interactions with amoebae suggest an explanation for its virulence and intracellular pathogenic strategy in macrophages.

Authors:  J N Steenbergen; H A Shuman; A Casadevall
Journal:  Proc Natl Acad Sci U S A       Date:  2001-12-11       Impact factor: 11.205

Review 4.  Intracellular parasitism of macrophages by Cryptococcus neoformans.

Authors:  M Feldmesser; S Tucker; A Casadevall
Journal:  Trends Microbiol       Date:  2001-06       Impact factor: 17.079

5.  Ceramide biosynthesis is required for the formation of the oligomeric H+-ATPase Pma1p in the yeast endoplasmic reticulum.

Authors:  Marcus C S Lee; Susan Hamamoto; Randy Schekman
Journal:  J Biol Chem       Date:  2002-04-11       Impact factor: 5.157

6.  Sphingomyelin turnover induced by vitamin D3 in HL-60 cells. Role in cell differentiation.

Authors:  T Okazaki; R M Bell; Y A Hannun
Journal:  J Biol Chem       Date:  1989-11-15       Impact factor: 5.157

7.  Induction of a novel class of diacylglycerol acyltransferases and triacylglycerol accumulation in Mycobacterium tuberculosis as it goes into a dormancy-like state in culture.

Authors:  Jaiyanth Daniel; Chirajyoti Deb; Vinod S Dubey; Tatiana D Sirakova; Bassam Abomoelak; Hector R Morbidoni; Pappachan E Kolattukudy
Journal:  J Bacteriol       Date:  2004-08       Impact factor: 3.490

8.  Isolation of Cryptococcus neoformans var. gattii from an Asian patient in France: evidence for dormant infection in healthy subjects.

Authors:  F Dromer; O Ronin; B Dupont
Journal:  J Med Vet Mycol       Date:  1992

9.  The sphingolipid pathway regulates Pkc1 through the formation of diacylglycerol in Cryptococcus neoformans.

Authors:  Lena J Heung; Chiara Luberto; Allyson Plowden; Yusuf A Hannun; Maurizio Del Poeta
Journal:  J Biol Chem       Date:  2004-03-10       Impact factor: 5.157

10.  Functional analysis of ISC1 by site-directed mutagenesis.

Authors:  Yasuo Okamoto; Silvia Vaena de Avalos; Yusuf A Hannun
Journal:  Biochemistry       Date:  2003-07-01       Impact factor: 3.162
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  14 in total

1.  Analysis of sphingolipids, sterols, and phospholipids in human pathogenic Cryptococcus strains.

Authors:  Ashutosh Singh; Andrew MacKenzie; Geoffrey Girnun; Maurizio Del Poeta
Journal:  J Lipid Res       Date:  2017-08-15       Impact factor: 5.922

2.  Identification of Antifungal Compounds against Multidrug-Resistant Candida auris Utilizing a High-Throughput Drug-Repurposing Screen.

Authors:  Yu-Shan Cheng; Jose Santinni Roma; Min Shen; Caroline Mota Fernandes; Patricia S Tsang; He Eun Forbes; Helena Boshoff; Cristina Lazzarini; Maurizio Del Poeta; Wei Zheng; Peter R Williamson
Journal:  Antimicrob Agents Chemother       Date:  2021-03-18       Impact factor: 5.191

3.  Identification of the galactosyltransferase of Cryptococcus neoformans involved in the biosynthesis of basidiomycete-type glycosylinositolphosphoceramide.

Authors:  Therese Wohlschlager; Reto Buser; Michael L Skowyra; Brian C Haynes; Bernard Henrissat; Tamara L Doering; Markus Künzler; Markus Aebi
Journal:  Glycobiology       Date:  2013-08-06       Impact factor: 4.313

4.  Fbp1-mediated ubiquitin-proteasome pathway controls Cryptococcus neoformans virulence by regulating fungal intracellular growth in macrophages.

Authors:  Tong-Bao Liu; Chaoyang Xue
Journal:  Infect Immun       Date:  2013-11-18       Impact factor: 3.441

5.  Inositol phosphosphingolipid phospholipase C1 regulates plasma membrane ATPase (Pma1) stability in Cryptococcus neoformans.

Authors:  Amir M Farnoud; Visesato Mor; Ashutosh Singh; Maurizio Del Poeta
Journal:  FEBS Lett       Date:  2014-09-18       Impact factor: 4.124

Review 6.  Virulence-Associated Enzymes of Cryptococcus neoformans.

Authors:  Fausto Almeida; Julie M Wolf; Arturo Casadevall
Journal:  Eukaryot Cell       Date:  2015-10-09

7.  Hydroxyurea treatment inhibits proliferation of Cryptococcus neoformans in mice.

Authors:  Kaushlendra Tripathi; Visesato Mor; Narendra K Bairwa; Maurizio Del Poeta; Bidyut K Mohanty
Journal:  Front Microbiol       Date:  2012-05-24       Impact factor: 5.640

8.  Cryptococcus neoformans modulates extracellular killing by neutrophils.

Authors:  Asfia Qureshi; Angus Grey; Kristie L Rose; Kevin L Schey; Maurizio Del Poeta
Journal:  Front Microbiol       Date:  2011-09-21       Impact factor: 5.640

9.  Developmentally regulated sphingolipid degradation in Leishmania major.

Authors:  Ou Zhang; Wei Xu; Agiesh Balakrishna Pillai; Kai Zhang
Journal:  PLoS One       Date:  2012-01-27       Impact factor: 3.240

Review 10.  Role of Inositol Phosphosphingolipid Phospholipase C1, the Yeast Homolog of Neutral Sphingomyelinases in DNA Damage Response and Diseases.

Authors:  Kaushlendra Tripathi
Journal:  J Lipids       Date:  2015-08-06
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