UNLABELLED: Inflammatory Bowel Diseases (IBDs) are chronic, relapsing and remitting gastrointestinal conditions with no known cure. Previous studies have linked behavioral factors, including stress and medication adherence, to relapse. PURPOSE: We sought to determine the effect of participation in a behavioral self-management program on incidence of flare within 12 months following behavioral intervention when compared to the natural history of flare incidence prior to program participation. RESULTS: Results from a 2-level regression model indicated that those participants in the treatment group were 57% less likely to flare in the following 12 months (compared to 18% in the control group). The decline in "flare odds" was about 2 times greater in treatment versus controls (OR=0.52, t(34)=2.07, p<0.05). Office visits, ER visits, and disease severity (all p<0.05) were identified as moderators of flare risk. CONCLUSIONS: We have demonstrated 1) a statistical model estimating the likelihood of flare rates in the 12 months following a behavioral intervention for IBD (compared to a control condition), and 2) that the introduction of a behavioral intervention can alter the natural course of a chronic, relapsing and remitting gastrointestinal condition such as IBD.
UNLABELLED: Inflammatory Bowel Diseases (IBDs) are chronic, relapsing and remitting gastrointestinal conditions with no known cure. Previous studies have linked behavioral factors, including stress and medication adherence, to relapse. PURPOSE: We sought to determine the effect of participation in a behavioral self-management program on incidence of flare within 12 months following behavioral intervention when compared to the natural history of flare incidence prior to program participation. RESULTS: Results from a 2-level regression model indicated that those participants in the treatment group were 57% less likely to flare in the following 12 months (compared to 18% in the control group). The decline in "flare odds" was about 2 times greater in treatment versus controls (OR=0.52, t(34)=2.07, p<0.05). Office visits, ER visits, and disease severity (all p<0.05) were identified as moderators of flare risk. CONCLUSIONS: We have demonstrated 1) a statistical model estimating the likelihood of flare rates in the 12 months following a behavioral intervention for IBD (compared to a control condition), and 2) that the introduction of a behavioral intervention can alter the natural course of a chronic, relapsing and remitting gastrointestinal condition such as IBD.
Authors: Geert D'Haens; William J Sandborn; Brian G Feagan; Karel Geboes; Stephen B Hanauer; E Jan Irvine; Marc Lémann; Philippe Marteau; Paul Rutgeerts; Jurgen Schölmerich; Lloyd R Sutherland Journal: Gastroenterology Date: 2006-12-20 Impact factor: 22.682
Authors: Joel E Mawdsley; Marion G Macey; Roger M Feakins; Louise Langmead; David S Rampton Journal: Gastroenterology Date: 2006-08 Impact factor: 22.682
Authors: Ashwin N Ananthakrishnan; Lydia R Weber; Josh F Knox; Susan Skaros; Jeanne Emmons; Sarah Lundeen; Mazen Issa; Mary F Otterson; David G Binion Journal: Am J Gastroenterol Date: 2007-12-11 Impact factor: 10.864
Authors: L Keefer; T H Taft; J L Kiebles; Z Martinovich; T A Barrett; O S Palsson Journal: Aliment Pharmacol Ther Date: 2013-08-19 Impact factor: 8.171
Authors: Anja Berding; Christine Witte; Marion Gottschald; Birgit Kaltz; Romy Weiland; Christian Gerlich; Andrea Reusch; Wolfgang Kruis; Hermann Faller Journal: Inflamm Intest Dis Date: 2016-11-30