| Literature DB >> 21256005 |
Jonathan Y Bass1, Justin A Caravella, Lihong Chen, Katrina L Creech, David N Deaton, Kevin P Madauss, Harry B Marr, Robert B McFadyen, Aaron B Miller, Wendy Y Mills, Frank Navas, Derek J Parks, Terrence L Smalley, Paul K Spearing, Dan Todd, Shawn P Williams, G Bruce Wisely.
Abstract
To improve on the drug properties of GSK8062 1b, a series of heteroaryl bicyclic naphthalene replacements were prepared. The quinoline 1c was an equipotent FXR agonist with improved drug developability parameters relative to 1b. In addition, analog 1c lowered body weight gain and serum glucose in a DIO mouse model of diabetes.Entities:
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Year: 2010 PMID： 21256005 DOI： 10.1016/j.bmcl.2010.12.089
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823